PDF(Pubmed)
Abstract：
UNASSIGNED: Granulomatous cutaneous T-cell lymphoma includes mycosis fungoides with significant granulomatous inflammation (GMF) and granulomatous slack skin (GSS), listed in the WHO classification as a subtype of mycosis fungoides (MFs). 1 These overlapping entities have shared clinical and histopathologic features which can present a diagnostic challenge. The dominance of the granulomatous infiltrate and the often sparse lymphocytic infiltrate frequently with minimal cytological atypia are features that distract from the correct diagnosis, even when raised by the clinician. We describe the clinical and histopathologic characteristics of 3 cases of granulomatous cutaneous T-cell lymphoma, illustrate the close clinical and pathologic relationship between GMF and GSS and emphasize the diagnostic difficulties that the granulomatous infiltrate can present. Furthermore, we demonstrate, for the first time, considerable elastolysis in a significant proportion of classical (Alibert-Bazin) MF lesions and therefore postulate that the differences observed between GMF and GSS are one of degree and secondary to their anatomic location rather than reflecting meaningful separate entities.
摘要：
■肉芽肿性皮肤T细胞淋巴瘤包括具有明显肉芽肿性炎症（GMF）和肉芽肿性松弛皮肤（GSS）的真菌病，在WHO分类中列为真菌病（MFs）的亚型。1这些重叠的实体具有共同的临床和组织病理学特征，可以提出诊断挑战。肉芽肿浸润的优势和经常稀疏的淋巴细胞浸润，通常具有最小的细胞学异型性，这些特征分散了正确的诊断，即使由临床医生抚养。我们描述了3例肉芽肿性皮肤T细胞淋巴瘤的临床和组织病理学特征，说明GMF和GSS之间的密切临床和病理关系，并强调肉芽肿浸润可能存在的诊断困难。此外，我们展示，第一次,在相当大比例的经典（Alibert-Bazin）MF病变中，有相当大的弹性溶解，因此假定GMF和GSS之间观察到的差异是其解剖位置的程度之一，是次要的，而不是反映有意义的单独实体。
