PDF(Pubmed)
Abstract：
Patients with mandibular conventional ameloblastoma undergoing radical surgical treatment experience greater trauma and often find it challenging to accept, whereas conservative therapy is associated with a higher recurrence rate. In this study, we have improved traditional conservative treatment for mandibular conventional ameloblastoma by curettage combined with bone cavity opening (Cur/BCO). This retrospective study aimed to evaluate the effectiveness of the Cur/BCO treatment by comparing its recurrence rate and bone mineral density (BMD) growth rate with the traditional conservative treatment approach.
A total of 40 patients, meeting the study\'s inclusion and exclusion criteria from 2012 to 2020, were screened, with 20 in the modified group and 20 in the traditional group. ImageJ (RRID: SCR_003070) software was employed for measuring image indices. All data were analyzed using T-test, Chi-square test and Fisher exact test in SPSS 26.0 (p = 0.05).
The incidence of recurrence was significantly lower in the modified group, at only 5%, compared to 35% in the traditional group (p < 0.05). Regarding bone mineral density (BMD) growth rate, the average value in the modified group was 0.0862 ± 0.2302 (/month), significantly higher than the average value of 0.0608 ± 0.2474 (/month) in the traditional group (p < 0.05).
In this study, it was found that the recurrence rate of the modified conservative treatment (Cur/BCO) was lower than that of the traditional conservative treatment for managing mandibular conventional ameloblastoma. Furthermore, the BMD growth rate was quicker in the modified group. Thus, Cur/BCO could be considered as a viable option for the conservative treatment of mandibular conventional ameloblastoma.
A total of 40 patients, meeting the study\'s inclusion and exclusion criteria from 2012 to 2020, were screened, with 20 in the modified group and 20 in the traditional group. ImageJ (RRID: SCR_003070) software was employed for measuring image indices. All data were analyzed using T-test, Chi-square test and Fisher exact test in SPSS 26.0 (p = 0.05).
The incidence of recurrence was significantly lower in the modified group, at only 5%, compared to 35% in the traditional group (p < 0.05). Regarding bone mineral density (BMD) growth rate, the average value in the modified group was 0.0862 ± 0.2302 (/month), significantly higher than the average value of 0.0608 ± 0.2474 (/month) in the traditional group (p < 0.05).
In this study, it was found that the recurrence rate of the modified conservative treatment (Cur/BCO) was lower than that of the traditional conservative treatment for managing mandibular conventional ameloblastoma. Furthermore, the BMD growth rate was quicker in the modified group. Thus, Cur/BCO could be considered as a viable option for the conservative treatment of mandibular conventional ameloblastoma.
摘要：
背景：接受根治性手术治疗的下颌常规成釉细胞瘤患者遭受更大的创伤，并且经常发现难以接受，而保守治疗与较高的复发率相关。在这项研究中,我们通过刮除结合骨腔开放（Cur/BCO）改进了传统的保守治疗下颌常规成釉细胞瘤的方法。这项回顾性研究旨在通过比较Cur/BCO治疗与传统保守治疗方法的复发率和骨密度（BMD）增长率来评估Cur/BCO治疗的有效性。
方法：共40例患者，从2012年到2020年，符合研究的纳入和排除标准，进行了筛选，改良组中有20个，传统组中有20个。使用ImageJ(RRID:SCR_003070)软件测量图像指数。所有数据采用T检验分析，SPSS26.0中的卡方检验和Fisher精确检验(p=0.05)。
结果：改良组的复发率明显降低，只有5%,与传统组的35%相比(p<0.05)。关于骨密度（BMD）增长率，改良组平均值为0.0862±0.2302(/月),显著高于传统组0.0608±0.2474(/月)的平均值(p<0.05)。
结论：在这项研究中，发现改良保守治疗（Cur/BCO）的复发率低于传统保守治疗的下颌骨常规成釉细胞瘤。此外，改良组的BMD增长率更快。因此，Cur/BCO可以被认为是保守治疗下颌常规成釉细胞瘤的可行选择。
方法：共40例患者，从2012年到2020年，符合研究的纳入和排除标准，进行了筛选，改良组中有20个，传统组中有20个。使用ImageJ(RRID:SCR_003070)软件测量图像指数。所有数据采用T检验分析，SPSS26.0中的卡方检验和Fisher精确检验(p=0.05)。
结果：改良组的复发率明显降低，只有5%,与传统组的35%相比(p<0.05)。关于骨密度（BMD）增长率，改良组平均值为0.0862±0.2302(/月),显著高于传统组0.0608±0.2474(/月)的平均值(p<0.05)。
结论：在这项研究中，发现改良保守治疗（Cur/BCO）的复发率低于传统保守治疗的下颌骨常规成釉细胞瘤。此外，改良组的BMD增长率更快。因此，Cur/BCO可以被认为是保守治疗下颌常规成釉细胞瘤的可行选择。
