Abstract：
BACKGROUND: Narrowband ultraviolet B (NB-UVB) phototherapy is the cornerstone of vitiligo treatment. Its combination with other treatments usually yields a better response. Latanoprost, a prostaglandin F2α analog, and autologous platelet-rich plasma (PRP) have been reported to be effective for vitiligo.
OBJECTIVE: To evaluate the efficacy of NB-UVB combined with intralesional latanoprost or PRP for stable nonsegmental vitiligo (NSV).
METHODS: Sixty patients with stable NSV were recruited and randomly allocated to two equal groups. NB-UVB phototherapy was administered twice a week for all patients. Additionally, group A received intralesional latanoprost injections once weekly, while group B received intralesional autologous PRP injections every 2 weeks.
RESULTS: At 24 weeks, excellent repigmentation response was observed in 26.7% and 13.3% of patients in the latanoprost/NB-UVB and PRP/NB-UVB groups, respectively, with no significant difference in degrees of repigmentation between the two groups. However, the Vitiligo Extent Score for a Target Area (VESTA) score was significantly higher in the latanoprost/NB-UVB group (p = .032). Moreover, lesions located on nonacral skin responded significantly better than those on acral skin. Only erythema was significantly higher in the PRP/NB-UVB group, while the recurrence of depigmentation was significantly higher in the latanoprost/NB-UVB group.
CONCLUSIONS: Both latanoprost and PRP have the potential to be effective add-on therapies to NB-UVB phototherapy for stable NSV, with latanoprost resulting in a greater repigmentation response and PRP producing a more stable response.
OBJECTIVE: To evaluate the efficacy of NB-UVB combined with intralesional latanoprost or PRP for stable nonsegmental vitiligo (NSV).
METHODS: Sixty patients with stable NSV were recruited and randomly allocated to two equal groups. NB-UVB phototherapy was administered twice a week for all patients. Additionally, group A received intralesional latanoprost injections once weekly, while group B received intralesional autologous PRP injections every 2 weeks.
RESULTS: At 24 weeks, excellent repigmentation response was observed in 26.7% and 13.3% of patients in the latanoprost/NB-UVB and PRP/NB-UVB groups, respectively, with no significant difference in degrees of repigmentation between the two groups. However, the Vitiligo Extent Score for a Target Area (VESTA) score was significantly higher in the latanoprost/NB-UVB group (p = .032). Moreover, lesions located on nonacral skin responded significantly better than those on acral skin. Only erythema was significantly higher in the PRP/NB-UVB group, while the recurrence of depigmentation was significantly higher in the latanoprost/NB-UVB group.
CONCLUSIONS: Both latanoprost and PRP have the potential to be effective add-on therapies to NB-UVB phototherapy for stable NSV, with latanoprost resulting in a greater repigmentation response and PRP producing a more stable response.
摘要：
背景：窄带紫外线B（NB-UVB）光疗是白癜风治疗的基石。它与其他治疗的组合通常会产生更好的反应。拉坦前列素,前列腺素F2α类似物，据报道，自体富血小板血浆（PRP）对白癜风有效。
目的：评价NB-UVB联合病变内拉坦前列素或PRP治疗稳定型非节段白癜风的疗效。
方法：纳入60例稳定的NSV患者，随机分为两组。所有患者每周两次给予NB-UVB光疗。此外,A组每周接受一次病灶内注射拉坦前列素，B组每2周接受一次病灶内自体PRP注射。
结果：在24周，在拉坦前列素/NB-UVB和PRP/NB-UVB组中，分别有26.7％和13.3％的患者观察到优异的色素沉着反应，分别,两组的再色素沉着程度无显著差异。然而,拉坦前列素/NB-UVB组的目标区域白癜风程度评分（VESTA）评分明显更高（p=.032）。此外，位于非肢端皮肤上的病变的反应明显优于肢端皮肤上的病变。PRP/NB-UVB组只有红斑显著增高,而拉坦前列素/NB-UVB组色素脱失的复发率明显更高。
结论：拉坦前列素和PRP都有可能成为NB-UVB光疗的有效附加疗法，用于稳定的NSV，拉坦前列素导致更大的色素沉着反应和PRP产生更稳定的反应。
目的：评价NB-UVB联合病变内拉坦前列素或PRP治疗稳定型非节段白癜风的疗效。
方法：纳入60例稳定的NSV患者，随机分为两组。所有患者每周两次给予NB-UVB光疗。此外,A组每周接受一次病灶内注射拉坦前列素，B组每2周接受一次病灶内自体PRP注射。
结果：在24周，在拉坦前列素/NB-UVB和PRP/NB-UVB组中，分别有26.7％和13.3％的患者观察到优异的色素沉着反应，分别,两组的再色素沉着程度无显著差异。然而,拉坦前列素/NB-UVB组的目标区域白癜风程度评分（VESTA）评分明显更高（p=.032）。此外，位于非肢端皮肤上的病变的反应明显优于肢端皮肤上的病变。PRP/NB-UVB组只有红斑显著增高,而拉坦前列素/NB-UVB组色素脱失的复发率明显更高。
结论：拉坦前列素和PRP都有可能成为NB-UVB光疗的有效附加疗法，用于稳定的NSV，拉坦前列素导致更大的色素沉着反应和PRP产生更稳定的反应。
