OBJECTIVE: To evaluate the efficacy of NB-UVB combined with intralesional latanoprost or PRP for stable nonsegmental vitiligo (NSV).
METHODS: Sixty patients with stable NSV were recruited and randomly allocated to two equal groups. NB-UVB phototherapy was administered twice a week for all patients. Additionally, group A received intralesional latanoprost injections once weekly, while group B received intralesional autologous PRP injections every 2 weeks.
RESULTS: At 24 weeks, excellent repigmentation response was observed in 26.7% and 13.3% of patients in the latanoprost/NB-UVB and PRP/NB-UVB groups, respectively, with no significant difference in degrees of repigmentation between the two groups. However, the Vitiligo Extent Score for a Target Area (VESTA) score was significantly higher in the latanoprost/NB-UVB group (p = .032). Moreover, lesions located on nonacral skin responded significantly better than those on acral skin. Only erythema was significantly higher in the PRP/NB-UVB group, while the recurrence of depigmentation was significantly higher in the latanoprost/NB-UVB group.
CONCLUSIONS: Both latanoprost and PRP have the potential to be effective add-on therapies to NB-UVB phototherapy for stable NSV, with latanoprost resulting in a greater repigmentation response and PRP producing a more stable response.
目的:评价NB-UVB联合病变内拉坦前列素或PRP治疗稳定型非节段白癜风的疗效。
方法:纳入60例稳定的NSV患者,随机分为两组。所有患者每周两次给予NB-UVB光疗。此外,A组每周接受一次病灶内注射拉坦前列素,B组每2周接受一次病灶内自体PRP注射。
结果:在24周,在拉坦前列素/NB-UVB和PRP/NB-UVB组中,分别有26.7%和13.3%的患者观察到优异的色素沉着反应,分别,两组的再色素沉着程度无显著差异。然而,拉坦前列素/NB-UVB组的目标区域白癜风程度评分(VESTA)评分明显更高(p=.032)。此外,位于非肢端皮肤上的病变的反应明显优于肢端皮肤上的病变。PRP/NB-UVB组只有红斑显著增高,而拉坦前列素/NB-UVB组色素脱失的复发率明显更高。
结论:拉坦前列素和PRP都有可能成为NB-UVB光疗的有效附加疗法,用于稳定的NSV,拉坦前列素导致更大的色素沉着反应和PRP产生更稳定的反应。