Abstract：
Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase. The dysregulation of SYK is closely related to the occurrence and development of allergic diseases, autoimmune diseases and cancer. SYK has become an attractive target for drug discovery due to its important biological functions. This article reviews the biological function of SYK, the relationship between SYK and disease, and therapies targeting SYK. In addition, inspired by new technologies such as proteolysis targeting chimeras (PROTACs) and phosphatase recruiting chimeras (PHORCs), we propose the development of new therapeutic approaches for targeting SYK, such as SYK PROTACs and SYK PHORCs, which may overcome deficiencies of existing methods.
摘要：
脾酪氨酸激酶(SYK)是非受体酪氨酸激酶。SYK调节异常与过敏性疾病的发生发展密切相关,自身免疫性疾病和癌症。SYK由于其重要的生物学功能而成为药物发现的有吸引力的靶标。本文综述了SYK的生物学功能,SYK与疾病的关系,和针对SYK的疗法。此外,受到蛋白水解靶向嵌合体（PROTACs）和磷酸酶募集嵌合体（PHORC）等新技术的启发，我们建议开发新的靶向SYK的治疗方法，例如SYKPROTACs和SYKPHORC，这可以克服现有方法的不足。
