PDF(Pubmed)
Abstract：
The aim of the study was to establish reference values for plasma bile acid (BA) concentrations in a collection of healthy green iguanas and to compare the results with BA concentrations in iguana patients presented to the clinic with various types of chronic liver diseases, patients with other chronic diseases and healthy iguanas that were presented for routine or pre-surgical health check-up. The concentration of BA was determined using the enzymatic colorimetric method. Mean plasma bile acid concentration in 110 samples from healthy green iguanas fasted for 24 h was higher (15.89 ± 15.61 μmol/l) than plasma bile acid concentration in the same iguanas fasted for 48 h (9.56 ± 8.52 μmol/l) (P < 0.01). The 3α-hydroxy bile acid concentration was significantly altered in 9 patients suffering from chronic liver diseases (diagnosed by histology) (84.85 ± 22.29 μmol/l). BA concentration in one iguana with hepatocellular adenoma (13.0 μmol/l) was within the interval of BA in healthy iguanas. Mean plasma BA concentration in 10 green iguanas that were suffering from various types of chronic diseases, but without any hepatopathy was 7.85 ± 4.86 μmol/l. The mean plasma BA concentration in 18 samples from green iguanas presented to the clinic for routine health check-ups and 17 green iguana females with preovulatory follicle stasis (POFS) syndrome presented for ovariectomy was 11.95 ± 9.43 μmol/l and 12.97 ± 9.06 μmol/l, respectively. The data collected from this study suggest that plasma bile acids are significantly increased in green iguanas suffering from chronic liver diseases.
摘要：
该研究的目的是建立一组健康的绿鬣蜥中血浆胆汁酸（BA）浓度的参考值，并将结果与临床上患有各种类型慢性肝病的鬣蜥患者的BA浓度进行比较，接受常规或术前健康检查的患有其他慢性疾病和健康鬣蜥的患者。使用酶比色法测定BA的浓度。禁食24h的110例健康绿鬣蜥的平均血浆胆汁酸浓度（15.89±15.61μmol/l）高于禁食48h的血浆胆汁酸浓度（9.56±8.52μmol/l）（P<0.01）。9例慢性肝病患者（通过组织学诊断）的3α-羟基胆汁酸浓度显着改变（84.85±22.29μmol/l）。一只患有肝细胞腺瘤的鬣蜥的BA浓度（13.0μmol/l）在健康鬣蜥的BA间隔内。平均血浆BA浓度在10绿鬣蜥患有各种慢性疾病，但无任何肝病的患者为7.85±4.86μmol/l。18例绿鬣蜥样本的平均血浆BA浓度为11.95±9.43μmol/l和12.97±9.06μmol/l。/l，分别。从这项研究中收集的数据表明，患有慢性肝病的绿鬣蜥的血浆胆汁酸显着增加。
