Abstract：
A number of medical conditions are identified as risk factors for suicide death; in particular, cardiovascular illnesses are recognized as a major suicide risk factor. In this case, self-poisoning is the common method of suicide and cardiovascular drugs are among the major medications associated with fatal overdose, with calcium channel blockers being one of the most common agents. The present study describes two different fatal suicide cases involving four cardiovascular drugs: carvedilol, doxazosin and amlodipine (case 1) and diltiazem (case 2). The concentrations of the target cardiovascular drugs in the different biological specimens (central and femoral blood, urine, liver, brain) are presented, giving information about the potentially fatal data and the distribution of the drugs in the body. The study led to the implementation of a fast, sensitive and simple method for the detection and quantification of the four commonly prescribed cardiovascular drugs in post-mortem specimens including fluids and tissues for forensic purposes. The method was fully validated. The toxicological results of the studied cases are discussed, along with the autopsy results, histopathological evidence, and circumstances of death. The toxicological findings presented in the study provide new data regarding cardiovascular drugs in different post-mortem specimens, which will contribute to the currently limited knowledge about the toxicological profile of cardiovascular drugs and their distribution.
摘要：
许多医疗状况被确定为自杀死亡的危险因素；特别是，心血管疾病被认为是主要的自杀危险因素。在这种情况下,自我中毒是自杀的常见方法，心血管药物是与致命过量相关的主要药物之一，钙通道阻滞剂是最常见的药物之一。本研究描述了两种不同的致命自杀病例，涉及四种心血管药物：卡维地洛，多沙唑嗪和氨氯地平（病例1）和地尔硫卓（病例2）。目标心血管药物在不同生物标本中的浓度（中央和股血液，尿液,肝脏,大脑)被呈现，提供有关潜在致命数据和药物在体内分布的信息。这项研究导致了一项快速的实施，灵敏而简单的方法，用于检测和定量验尸标本中的四种常用心血管药物，包括用于法医目的的液体和组织。该方法得到了充分的验证。讨论了研究案例的毒理学结果，连同尸检结果,组织病理学证据,和死亡的情况。研究中提出的毒理学发现提供了有关不同死后标本中心血管药物的新数据，这将有助于目前对心血管药物及其分布的毒理学概况的有限了解。
