Abstract：
UNASSIGNED: The objective of this study was to identify and determine factors associated with patients\' ophthalmic adherence in common ocular conditions from randomized clinical trials (RCT).
UNASSIGNED: A univariate analysis with proportions, a bivariate analysis using polychoric correlations, and logistic regression (LR) models were used. The collected dataset was made up of records from RCT. Using three validated LR models, factors were identified and ranked based on their adjusted odds ratio and their statistical significance to adherence.
UNASSIGNED: A total of 1,087 valid patients were included in this analysis, of which 88.96% presented adherence. All models were calibrated, had a good performance, were well specified and cost-effective using the Hosmer-Lemeshow test, metrics for class imbalance, link test approach and Akaike\'s criteriums, respectively.
UNASSIGNED: We identified as determinants for encouraging good ophthalmic adherence the adverse events presented, duration of the study, female sex, and older age; other determinants such as medical condition, protocol treatment, type of treatment and disease are all risk factors for adherence. Improvements in ophthalmic adherence may be achieved by focused attention to young male patients with chronic degenerative diseases such as glaucoma or ocular hypertension (especially those who need combination therapy) and developing medications with reduced side effects.
UNASSIGNED: A univariate analysis with proportions, a bivariate analysis using polychoric correlations, and logistic regression (LR) models were used. The collected dataset was made up of records from RCT. Using three validated LR models, factors were identified and ranked based on their adjusted odds ratio and their statistical significance to adherence.
UNASSIGNED: A total of 1,087 valid patients were included in this analysis, of which 88.96% presented adherence. All models were calibrated, had a good performance, were well specified and cost-effective using the Hosmer-Lemeshow test, metrics for class imbalance, link test approach and Akaike\'s criteriums, respectively.
UNASSIGNED: We identified as determinants for encouraging good ophthalmic adherence the adverse events presented, duration of the study, female sex, and older age; other determinants such as medical condition, protocol treatment, type of treatment and disease are all risk factors for adherence. Improvements in ophthalmic adherence may be achieved by focused attention to young male patients with chronic degenerative diseases such as glaucoma or ocular hypertension (especially those who need combination therapy) and developing medications with reduced side effects.
摘要：
■本研究的目的是从随机临床试验（RCT）中确定和确定与患者在常见眼部疾病中的眼科依从性相关的因素。
■比例的单变量分析，使用多脉络相关性的双变量分析，并使用逻辑回归(LR)模型。收集的数据集由来自RCT的记录组成。使用三个经过验证的LR模型，根据因素的校正比值比及其对依从性的统计学意义进行鉴定和排名.
■本次分析共纳入1,087名有效患者，其中88.96%表示坚持。所有模型都经过校准,有一个很好的表现，使用Hosmer-Lemeshow测试，类不平衡的度量，链接测试方法和Akaike\的标准，分别。
■我们确定所出现的不良事件是鼓励良好眼科依从性的决定因素，研究的持续时间，女性性别,和年龄；其他决定因素，如医疗条件，协议治疗，治疗类型和疾病都是依从性的危险因素.可以通过集中关注患有慢性退行性疾病如青光眼或高眼压症的年轻男性患者(尤其是需要联合治疗的患者)并开发副作用减少的药物来实现眼科依从性的改善。
■比例的单变量分析，使用多脉络相关性的双变量分析，并使用逻辑回归(LR)模型。收集的数据集由来自RCT的记录组成。使用三个经过验证的LR模型，根据因素的校正比值比及其对依从性的统计学意义进行鉴定和排名.
■本次分析共纳入1,087名有效患者，其中88.96%表示坚持。所有模型都经过校准,有一个很好的表现，使用Hosmer-Lemeshow测试，类不平衡的度量，链接测试方法和Akaike\的标准，分别。
■我们确定所出现的不良事件是鼓励良好眼科依从性的决定因素，研究的持续时间，女性性别,和年龄；其他决定因素，如医疗条件，协议治疗，治疗类型和疾病都是依从性的危险因素.可以通过集中关注患有慢性退行性疾病如青光眼或高眼压症的年轻男性患者(尤其是需要联合治疗的患者)并开发副作用减少的药物来实现眼科依从性的改善。
