Abstract：
UNASSIGNED: Case studies reporting intraplacental choriocarcinoma (IPC) and intraplacental \"chorangiocarcinoma\" have recently increased, with IPC also represented in molecular analyses of gestational trophoblastic neoplasms.
UNASSIGNED: To provide an overview of 2 intraplacental neoplastic lesions that can have a significant impact on both mother and fetus/infant, focusing on diagnostic characteristics, and ancillary and molecular tools that support diagnosis, determine prognosis, and further elucidate the nature of these lesions.
UNASSIGNED: Data were compiled from a PubMed literature review that included diagnostic and additional keywords within the scope of study for gestational choriocarcinoma in general. Illustrative cases were retrieved from the pathology archives at Michigan Medicine, including the consultation files of the author.
UNASSIGNED: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called \"chorangiocarcinoma\" and chorangioma with atypical trophoblast proliferation, is also reviewed. The incidence of these lesions is likely to be underestimated. Heightened suspicion and more liberal placental sampling, particularly when specific clinical features are present, may result in higher detection. Enhanced detection to provide the earliest intervention for both mother and infant may improve prognosis, particularly for asymptomatic disease that may later present with metastasis.
UNASSIGNED: To provide an overview of 2 intraplacental neoplastic lesions that can have a significant impact on both mother and fetus/infant, focusing on diagnostic characteristics, and ancillary and molecular tools that support diagnosis, determine prognosis, and further elucidate the nature of these lesions.
UNASSIGNED: Data were compiled from a PubMed literature review that included diagnostic and additional keywords within the scope of study for gestational choriocarcinoma in general. Illustrative cases were retrieved from the pathology archives at Michigan Medicine, including the consultation files of the author.
UNASSIGNED: Intraplacental gestational tumors exist along the spectrum of benign (chorangioma) to aggressive malignant (choriocarcinoma) neoplasms with a high potential for metastasis. Although most gestational choriocarcinomas follow complete hydatidiform mole, 20% to 25% occur in association with normal intrauterine gestations, including rare cases in which they are detected within the placenta (IPC). IPCs range from asymptomatic to widely metastatic, with metastases possible even when only microscopic IPCs are present. A second, even less common lesion, variably called \"chorangiocarcinoma\" and chorangioma with atypical trophoblast proliferation, is also reviewed. The incidence of these lesions is likely to be underestimated. Heightened suspicion and more liberal placental sampling, particularly when specific clinical features are present, may result in higher detection. Enhanced detection to provide the earliest intervention for both mother and infant may improve prognosis, particularly for asymptomatic disease that may later present with metastasis.
摘要：
■报告胎盘内绒毛膜癌（IPC）和胎盘内“脉络膜癌”的案例研究最近有所增加，与IPC也代表在妊娠滋养细胞肿瘤的分子分析。
■为了提供2种可能对母亲和胎儿/婴儿产生重大影响的胎盘内肿瘤病变的概述，专注于诊断特征，以及支持诊断的辅助和分子工具，确定预后，并进一步阐明这些病变的性质。
■数据来自PubMed文献综述，其中包括一般妊娠期绒毛膜癌研究范围内的诊断和其他关键词。从密歇根医学院的病理学档案中检索了说明性病例，包括作者的咨询文件。
■胎盘内妊娠肿瘤存在于良性（脉管瘤）到侵袭性恶性（绒毛膜癌）肿瘤的范围内，具有很高的转移潜力。虽然大多数妊娠脉络膜癌以完全葡萄胎为基础，20%至25%与正常宫内妊娠有关，包括在胎盘中检测到的罕见病例（IPC）。IPC的范围从无症状到广泛转移，即使仅存在微观IPC，也可能发生转移。一秒,甚至更不常见的病变，被称为“脉络膜癌”和具有非典型滋养细胞增殖的脉络膜瘤，也进行了审查。这些病变的发生率可能被低估。怀疑和更自由的胎盘取样，特别是当存在特定的临床特征时，可能导致更高的检测。增强检测以提供对母亲和婴儿的最早干预可能会改善预后，特别是对于后来可能出现转移的无症状疾病。
■为了提供2种可能对母亲和胎儿/婴儿产生重大影响的胎盘内肿瘤病变的概述，专注于诊断特征，以及支持诊断的辅助和分子工具，确定预后，并进一步阐明这些病变的性质。
■数据来自PubMed文献综述，其中包括一般妊娠期绒毛膜癌研究范围内的诊断和其他关键词。从密歇根医学院的病理学档案中检索了说明性病例，包括作者的咨询文件。
■胎盘内妊娠肿瘤存在于良性（脉管瘤）到侵袭性恶性（绒毛膜癌）肿瘤的范围内，具有很高的转移潜力。虽然大多数妊娠脉络膜癌以完全葡萄胎为基础，20%至25%与正常宫内妊娠有关，包括在胎盘中检测到的罕见病例（IPC）。IPC的范围从无症状到广泛转移，即使仅存在微观IPC，也可能发生转移。一秒,甚至更不常见的病变，被称为“脉络膜癌”和具有非典型滋养细胞增殖的脉络膜瘤，也进行了审查。这些病变的发生率可能被低估。怀疑和更自由的胎盘取样，特别是当存在特定的临床特征时，可能导致更高的检测。增强检测以提供对母亲和婴儿的最早干预可能会改善预后，特别是对于后来可能出现转移的无症状疾病。
