Abstract：
Cell counting in peripheral blood samples and their combinations have gained wide usage in clinical research due to their convenient and minimally invasive sampling method. This study aims to evaluate the predictive value of neutrophil-to-lymphocyte ratio (NLR), systemic Immunoinflammatory Index (SII), and systemic Inflammatory Response Index (SIRI), and platelet distribution width (PDW) for the occurrence of non-arteritic Central retinal artery occlusion (NA-CRAO).
We included 123 patients diagnosed with NA-CRAO and 120 age-, sex- and blood pressure-matched individuals in this study. All participants underwent a comprehensive ophthalmic assessment. Peripheral blood samples were retrospectively analysed to obtain patients\' blood counts and platelet-related indices, and further NLR, SII and SIRI were calculated.
NLR, SII, SIRI, and PDW were all found to be elevated and significantly different in NA-CRAO patients compared to controls (p < 0.05). Notably, elevated NLR and PDW were identified as independent influences on the development of NA-CRAO, with a combined predicted AUC of 0.876.
The utilization of NLR and PDW in NA-CRAO prediction may prove to be more effective compared to SII and SIRI.
We included 123 patients diagnosed with NA-CRAO and 120 age-, sex- and blood pressure-matched individuals in this study. All participants underwent a comprehensive ophthalmic assessment. Peripheral blood samples were retrospectively analysed to obtain patients\' blood counts and platelet-related indices, and further NLR, SII and SIRI were calculated.
NLR, SII, SIRI, and PDW were all found to be elevated and significantly different in NA-CRAO patients compared to controls (p < 0.05). Notably, elevated NLR and PDW were identified as independent influences on the development of NA-CRAO, with a combined predicted AUC of 0.876.
The utilization of NLR and PDW in NA-CRAO prediction may prove to be more effective compared to SII and SIRI.
摘要：
目的：外周血细胞计数及其组合方法因其方便、微创的取样方法在临床研究中得到了广泛的应用。本研究旨在评估中性粒细胞与淋巴细胞比率(NLR)的预测价值。全身免疫炎症指数（SII），和全身炎症反应指数（SIRI），非动脉炎性视网膜中央动脉阻塞（NA-CRAO）的发生和血小板分布宽度（PDW）。
方法：我们纳入了123例诊断为NA-CRAO和120岁的患者，这项研究中性别和血压匹配的个体。所有参与者都接受了全面的眼科评估。对外周血样本进行回顾性分析，以获得患者的血液计数和血小板相关指标，和进一步的NLR，计算SII和SIRI。
结果：NLR，SII,SIRI,与对照组相比，NA-CRAO患者和PDW均升高且差异显着（p<0.05）。值得注意的是,NLR和PDW升高被确定为对NA-CRAO发展的独立影响，联合预测AUC为0.876。
结论：与SII和SIRI相比，在NA-CRAO预测中利用NLR和PDW可能更有效。
方法：我们纳入了123例诊断为NA-CRAO和120岁的患者，这项研究中性别和血压匹配的个体。所有参与者都接受了全面的眼科评估。对外周血样本进行回顾性分析，以获得患者的血液计数和血小板相关指标，和进一步的NLR，计算SII和SIRI。
结果：NLR，SII,SIRI,与对照组相比，NA-CRAO患者和PDW均升高且差异显着（p<0.05）。值得注意的是,NLR和PDW升高被确定为对NA-CRAO发展的独立影响，联合预测AUC为0.876。
结论：与SII和SIRI相比，在NA-CRAO预测中利用NLR和PDW可能更有效。
