Abstract：
Objective: The purpose of this study was to compare the effectiveness of optimal pulsed technology (OPT) and meibomian gland massage (MGM) in alleviating the signs and symptoms of contact lens-related meibomian gland dysfunction (CL-MGD). Methods: This prospective, randomized, controlled study included 90 patients (180 eyes) diagnosed with CL-MGD and were assigned to the OPT group (n = 60 eyes), MGM group (n = 60 eyes), and control group (n = 60 eyes). All participants were examined at baseline (D0), day 21 (D21), and day 42 (D42) for the ocular surface disease index (OSDI), noninvasive tear break-up time (NITBUT), noninvasive tear meniscus height (NITMH), meibomian gland score (MGS), meibomian gland score (MGYSS), best-corrected visual acuity, and intraocular pressure. Results: The OSDI scores and NITBUT improved after treatment in all the three groups. The OSDI scores in OPT and MGM groups were significantly lower compared with that in the control group at D21 and further decreased at D42. The NITBUT in OPT and MGM groups increased compared with the control group at D21 and further increased at D42, and the NITBUT in OPT group increased compared with the MGM group at D21 and D42. The MGYSS both improved after treatment in the OPT and MGM groups, The MGYSS in OPT and MGM groups decreased compared with the control group at D21 and further decreased at D42, and the MGYSS in the OPT group decreased compared with the MGM group at D21 and D42. The NITMH and MGS had no differences after treatment. Conclusions: Results imply that OPT or MGM treatment can be safely used to relieve symptoms of CL-MGD. In addition, OPT treatment was found to be more effective in improving the general stability of the tear-film in CL-MGD.
摘要：
目的：本研究的目的是比较最佳脉冲技术（OPT）和睑板腺按摩（MGM）在缓解隐形眼镜相关性睑板腺功能障碍（CL-MGD）的体征和症状方面的有效性。方法：本前瞻性，随机化，对照研究包括90例（180只眼）诊断为CL-MGD的患者，并被分配到OPT组（n=60只眼），MGM组（n=60眼），对照组(n=60只眼)。所有参与者在基线(D0)检查，第21天（D21），眼表疾病指数(OSDI)和第42天(D42)，非侵入性泪液破裂时间（NITBUT），无创性撕裂半月板高度（NITMH），睑板腺评分（MGS），睑板腺评分（MGYSS），最佳矫正视力，和眼压。结果:3组治疗后OSDI评分和NITBUT均有改善。在D21时，OPT和MGM组的OSDI评分明显低于对照组，在D42时进一步降低。OPT和MGM组的NITBUT在D21时与对照组相比增加，在D42时进一步增加，并且OPT组的NITBUT在D21和D42时与MGM组相比增加。OPT组和MGM组治疗后MGYSS均有改善,OPT和MGM组的MGYSS在D21时较对照组降低,在D42时进一步降低,OPT组的MGYSS在D21和D42时较MGM组降低。NITMH和MGS治疗后无差异。结论：结果表明，OPT或MGM治疗可以安全地缓解CL-MGD的症状。此外,发现OPT治疗在改善CL-MGD中泪膜的总体稳定性方面更有效。
