Abstract：
Meniscus injuries are associated with the degeneration of cartilage and development of osteoarthritis (OA). It is challenging to protect articular cartilage and improve exercise when a meniscus injury occurs. Herein, inspired by the components and functions of the meniscus, we developed a self-lubricating and friction-responsive hydrogel that contains nanoliposomes loaded with diclofenac sodium (DS) and Kartogenin (KGN) for anti-inflammation and cartilage regeneration. When the hydrogel was injected into the meniscus injury site, the drug-loaded nanoliposomes were released from the hydrogel in a friction-responsive manner and reassembled to form hydration layers that lubricate joints during movement. Meanwhile, DS and KNG were constantly released from the nanoliposomes to mitigate inflammation and promote cartilage regeneration. Additionally, this hydrogel exhibited favorable injectability, mechanical properties, fatigue resistance, and prolonged degradation. In vivo experiments demonstrated that injection of the hydrogel effectively improved exercise performance and protected the articular cartilage of rats, suggesting it as a potential therapeutic approach for meniscal injuries.
摘要：
半月板损伤与软骨退化和骨关节炎（OA）的发展有关。当半月板损伤发生时,保护关节软骨和改善运动是具有挑战性的。在这里，受弯月面的成分和功能的启发，我们开发了一种自润滑和摩擦响应性的水凝胶，其中包含负载有双氯芬酸钠（DS）和KTogenin（KGN）的纳米脂质体，用于抗炎和软骨再生。当水凝胶被注射到半月板损伤部位时，负载药物的纳米脂质体以摩擦响应的方式从水凝胶中释放,并重新组装以形成在运动过程中润滑关节的水合层.同时,DS和KNG不断地从纳米脂质体中释放以减轻炎症并促进软骨再生。此外,这种水凝胶表现出良好的可注射性，机械性能，抗疲劳性，和长时间的退化。体内实验表明，水凝胶的注射有效地改善了运动能力，保护了大鼠的关节软骨，表明它是半月板损伤的潜在治疗方法。
