PDF(Pubmed)
Abstract：
Colorectal carcinoma is the third most common type of cancer. Although the role of matricellular proteins and their association with tumor progression is well documented, limited data are available concerning their involvement in colorectal cancer. The current study investigated the expression pattern of matricellular proteins SPARC and CYR61 with epithelial-mesenchymal transition proteins in human CRC tissues and unleashed their association with colorectal cancer progression. The expression of these proteins was associated with advancement in tumor staging, nodal metastasis, and vascular invasion. Elevated CYR61 protein levels were also consistent with higher mesenchymal markers ZEB1 and Vimentin in collected biopsies and CRC cells. Moreover, expression of CYR61 promoted CRC cell migration, invasion, proliferation, and apoptosis. Our findings conclusively revealed the significant involvement of CYR61 in CRC progression through activating epithelial-mesenchymal transition. This discovery holds great promise for advancing therapeutic approaches in the treatment of CRC.
摘要：
结直肠癌是第三常见的癌症类型。尽管基质细胞蛋白的作用及其与肿瘤进展的关系已得到充分证明，关于他们参与结直肠癌的数据有限.目前的研究调查了人CRC组织中基质细胞蛋白SPARC和CYR61与上皮-间质转化蛋白的表达模式，并揭示了它们与结直肠癌进展的关系。这些蛋白的表达与肿瘤分期的进展有关,淋巴结转移,和血管侵入。在收集的活检和CRC细胞中，升高的CYR61蛋白水平也与较高的间充质标志物ZEB1和波形蛋白一致。此外，CYR61的表达促进CRC细胞迁移，入侵,扩散,和凋亡。我们的发现最终揭示了CYR61通过激活上皮-间质转化在CRC进展中的重要参与。这一发现为推进CRC治疗的治疗方法带来了巨大的希望。
