PDF(Pubmed)
Abstract：
UNASSIGNED: Parkinson\'s disease (PD) is a neurodegenerative condition that is characterized by bradykinesia, rigidity, and gait instability. Inherent to this condition is an increased predisposition to falls and fractures. Bone health in Parkinson\'s disease in India has not been studied thus far. This study aimed to assess the bone mineral density (BMD), trabecular bone score (TBS), and hip structural analysis (HSA) in Indian men with PD and compare them with matched controls.
UNASSIGNED: A case-control study done at a tertiary care center from southern India. Bone biochemistry, BMD, TBS, and HSA were assessed.
UNASSIGNED: Among 40 cases and 40 age, gender, and body mass index (BMI)-matched controls, there was no significant difference in BMD between both groups. The mean (SD) TBS at the lumbar spine [1.349 (0.090)] was significantly (P = 0.019) lower in men with PD as compared to matched controls [1.401 (0.089)]. Among the parameters of HSA, the buckling ratios were significantly higher at the femoral neck [11.8 (2.2) vs 9.4 (2.2); P = 0.001] and inter-trochanteric region [9.4 (2.1) vs 7.8 (1.4); P = 0.002] among cases as compared to matched controls. Vitamin D deficiency was significantly higher in this cohort of patients as was bone turnover marker indicating bone loss and a high bone turnover state.
UNASSIGNED: A comprehensive bone health assessment comprising BMD, TBS, and HSA may be required to capture all aspects of bone strength in Indian men with PD as BMD assessment as a stand-alone tool may not suffice to obtain all information pertaining to fracture risk in these individuals.
UNASSIGNED: A case-control study done at a tertiary care center from southern India. Bone biochemistry, BMD, TBS, and HSA were assessed.
UNASSIGNED: Among 40 cases and 40 age, gender, and body mass index (BMI)-matched controls, there was no significant difference in BMD between both groups. The mean (SD) TBS at the lumbar spine [1.349 (0.090)] was significantly (P = 0.019) lower in men with PD as compared to matched controls [1.401 (0.089)]. Among the parameters of HSA, the buckling ratios were significantly higher at the femoral neck [11.8 (2.2) vs 9.4 (2.2); P = 0.001] and inter-trochanteric region [9.4 (2.1) vs 7.8 (1.4); P = 0.002] among cases as compared to matched controls. Vitamin D deficiency was significantly higher in this cohort of patients as was bone turnover marker indicating bone loss and a high bone turnover state.
UNASSIGNED: A comprehensive bone health assessment comprising BMD, TBS, and HSA may be required to capture all aspects of bone strength in Indian men with PD as BMD assessment as a stand-alone tool may not suffice to obtain all information pertaining to fracture risk in these individuals.
摘要：
■帕金森病（PD）是一种神经退行性疾病，其特征是运动迟缓，刚性,和步态不稳定。这种情况固有的是跌倒和骨折的倾向增加。到目前为止，印度尚未对帕金森氏病的骨骼健康进行研究。这项研究旨在评估骨矿物质密度（BMD），骨小梁评分(TBS),和髋关节结构分析（HSA）在印度男性PD，并与匹配的对照组进行比较。
■在印度南部的三级护理中心进行的病例对照研究。骨生物化学,BMD,TBS,和HSA进行评估。
■在40例和40岁的患者中，性别,和体重指数(BMI)匹配的对照，两组之间的BMD没有显着差异。与匹配的对照组[1.401(0.089)]相比,患有PD的男性的腰椎处的平均(SD)TBS[1.349(0.090)]显著(P=0.019)更低。在HSA的参数中，与对照组相比,股骨颈[11.8(2.2)比9.4(2.2);P=0.001]和股骨转子间[9.4(2.1)比7.8(1.4);P=0.002]的屈曲率显著高于对照组.在该队列患者中，维生素D缺乏明显更高，骨转换标志物表明骨丢失和高骨转换状态。
■全面的骨骼健康评估，包括BMD，TBS,并且可能需要HSA来捕获患有PD的印度男性的骨强度的所有方面，因为BMD评估作为独立工具可能不足以获得与这些个体的骨折风险有关的所有信息。
■在印度南部的三级护理中心进行的病例对照研究。骨生物化学,BMD,TBS,和HSA进行评估。
■在40例和40岁的患者中，性别,和体重指数(BMI)匹配的对照，两组之间的BMD没有显着差异。与匹配的对照组[1.401(0.089)]相比,患有PD的男性的腰椎处的平均(SD)TBS[1.349(0.090)]显著(P=0.019)更低。在HSA的参数中，与对照组相比,股骨颈[11.8(2.2)比9.4(2.2);P=0.001]和股骨转子间[9.4(2.1)比7.8(1.4);P=0.002]的屈曲率显著高于对照组.在该队列患者中，维生素D缺乏明显更高，骨转换标志物表明骨丢失和高骨转换状态。
■全面的骨骼健康评估，包括BMD，TBS,并且可能需要HSA来捕获患有PD的印度男性的骨强度的所有方面，因为BMD评估作为独立工具可能不足以获得与这些个体的骨折风险有关的所有信息。
