UNASSIGNED: A case-control study done at a tertiary care center from southern India. Bone biochemistry, BMD, TBS, and HSA were assessed.
UNASSIGNED: Among 40 cases and 40 age, gender, and body mass index (BMI)-matched controls, there was no significant difference in BMD between both groups. The mean (SD) TBS at the lumbar spine [1.349 (0.090)] was significantly (P = 0.019) lower in men with PD as compared to matched controls [1.401 (0.089)]. Among the parameters of HSA, the buckling ratios were significantly higher at the femoral neck [11.8 (2.2) vs 9.4 (2.2); P = 0.001] and inter-trochanteric region [9.4 (2.1) vs 7.8 (1.4); P = 0.002] among cases as compared to matched controls. Vitamin D deficiency was significantly higher in this cohort of patients as was bone turnover marker indicating bone loss and a high bone turnover state.
UNASSIGNED: A comprehensive bone health assessment comprising BMD, TBS, and HSA may be required to capture all aspects of bone strength in Indian men with PD as BMD assessment as a stand-alone tool may not suffice to obtain all information pertaining to fracture risk in these individuals.
■在印度南部的三级护理中心进行的病例对照研究。骨生物化学,BMD,TBS,和HSA进行评估。
■在40例和40岁的患者中,性别,和体重指数(BMI)匹配的对照,两组之间的BMD没有显着差异。与匹配的对照组[1.401(0.089)]相比,患有PD的男性的腰椎处的平均(SD)TBS[1.349(0.090)]显著(P=0.019)更低。在HSA的参数中,与对照组相比,股骨颈[11.8(2.2)比9.4(2.2);P=0.001]和股骨转子间[9.4(2.1)比7.8(1.4);P=0.002]的屈曲率显著高于对照组.在该队列患者中,维生素D缺乏明显更高,骨转换标志物表明骨丢失和高骨转换状态。
■全面的骨骼健康评估,包括BMD,TBS,并且可能需要HSA来捕获患有PD的印度男性的骨强度的所有方面,因为BMD评估作为独立工具可能不足以获得与这些个体的骨折风险有关的所有信息。