PDF(Pubmed)
Abstract：
UNASSIGNED: This systematic review summarizes available evidence on the relationship between white matter hyperintensities (WMH) volumetric quantification on brain MRI scans and chronic kidney disease (CKD).
UNASSIGNED: The literature search was performed in March 2022 using MEDLINE PubMed Central, Scopus and Web of Science - Publons as search engines. Relevant articles investigating, with a quantitative volumetric approach, the link between WMH and CKD patients were selected.
UNASSIGNED: The database search strategy found 987 articles, after excluding duplicates, the titles and abstracts of the remaining 320 articles were examined. Subsequently 276 articles were excluded as they were not relevant to the topic. Of the 44 articles evaluated for eligibility, 36 were excluded because the quantitative analysis of WMH was not volumetric. Finally, 8 articles were included in this systematic review.
UNASSIGNED: Literature on this topic is extremely heterogeneous in terms of methodology and samples. However, evidence shows that there is a relationship between CKD and WMH volume of the brain. We recommend that quantifiable biomarkers such as estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR) should be included in studies dealing with cerebrovascular disease. The biological and molecular mechanisms underlying cerebrovascular damage in patients with chronic renal failure deserve to be further explored.
UNASSIGNED: The literature search was performed in March 2022 using MEDLINE PubMed Central, Scopus and Web of Science - Publons as search engines. Relevant articles investigating, with a quantitative volumetric approach, the link between WMH and CKD patients were selected.
UNASSIGNED: The database search strategy found 987 articles, after excluding duplicates, the titles and abstracts of the remaining 320 articles were examined. Subsequently 276 articles were excluded as they were not relevant to the topic. Of the 44 articles evaluated for eligibility, 36 were excluded because the quantitative analysis of WMH was not volumetric. Finally, 8 articles were included in this systematic review.
UNASSIGNED: Literature on this topic is extremely heterogeneous in terms of methodology and samples. However, evidence shows that there is a relationship between CKD and WMH volume of the brain. We recommend that quantifiable biomarkers such as estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (UACR) should be included in studies dealing with cerebrovascular disease. The biological and molecular mechanisms underlying cerebrovascular damage in patients with chronic renal failure deserve to be further explored.
摘要：
■本系统综述总结了脑MRI扫描白质高信号（WMH）体积定量与慢性肾脏疾病（CKD）之间关系的现有证据。
■文献检索于2022年3月使用MEDLINEPubMedCentral进行，Scopus和WebofScience-作为搜索引擎的出版物。相关文章调查,用定量的体积方法，选择WMH和CKD患者之间的联系.
■数据库搜索策略找到了987篇文章，排除重复项后，检查了其余320篇文章的标题和摘要。随后，276篇文章被排除在外，因为它们与该主题无关。在评估资格的44篇文章中，排除了36例，因为WMH的定量分析不是体积的。最后,本系统综述共纳入8篇文章。
■关于这一主题的文献在方法和样本方面极其不同。然而,证据表明CKD与脑WMH体积之间存在关系。我们建议将可量化的生物标志物，例如估计的肾小球滤过率（eGFR）和尿白蛋白与肌酐之比（UACR）纳入治疗脑血管疾病的研究中。慢性肾功能衰竭患者脑血管损害的生物学和分子机制值得进一步探讨。
■文献检索于2022年3月使用MEDLINEPubMedCentral进行，Scopus和WebofScience-作为搜索引擎的出版物。相关文章调查,用定量的体积方法，选择WMH和CKD患者之间的联系.
■数据库搜索策略找到了987篇文章，排除重复项后，检查了其余320篇文章的标题和摘要。随后，276篇文章被排除在外，因为它们与该主题无关。在评估资格的44篇文章中，排除了36例，因为WMH的定量分析不是体积的。最后,本系统综述共纳入8篇文章。
■关于这一主题的文献在方法和样本方面极其不同。然而,证据表明CKD与脑WMH体积之间存在关系。我们建议将可量化的生物标志物，例如估计的肾小球滤过率（eGFR）和尿白蛋白与肌酐之比（UACR）纳入治疗脑血管疾病的研究中。慢性肾功能衰竭患者脑血管损害的生物学和分子机制值得进一步探讨。
