UNASSIGNED: An online electronic search was performed on PubMed, Web of Science, and Scopus of English-language literature with following keywords: cough, nitric oxide (NO), eosinophils, biomarker, and treatable trait. Relevance and eligibility of each article were assessed by one or more of the authors and a narrative review was composed.
UNASSIGNED: Eosinophilic or type 2 airway inflammation is a major treatable trait in patients with chronic cough. Induced sputum tests are regarded as the gold standard for defining inflammatory phenotype, however, technically demanding and cannot be widely applied in clinical practice. FeNO, a practical biomarker, has emerged as an alternative to induced sputum analyses. Mechanistic and clinical evidence indicated that FeNO had a potential for diagnostic utility and treatment response predictability.
UNASSIGNED: FeNO measurement may help to identify patients with chronic cough that will benefit from corticosteroid treatment. Further studies are warranted to determine the diagnostic roles of FeNO in the management of patients with chronic cough.
■在PubMed上进行了在线电子搜索,WebofScience,和英语文学的Scopus,关键词如下:咳嗽,一氧化氮(NO),嗜酸性粒细胞,生物标志物,和可治疗的特征。由一位或多位作者评估每篇文章的相关性和资格,并撰写叙述性评论。
■嗜酸性粒细胞或2型气道炎症是慢性咳嗽患者的主要可治疗特征。诱导痰试验被认为是定义炎症表型的金标准,然而,技术要求高,不能广泛应用于临床。FeNO,一个实用的生物标志物,已成为诱导痰分析的替代方法。机制和临床证据表明,FeNO具有诊断效用和治疗反应可预测性的潜力。
■FeNO测定可能有助于识别从皮质类固醇治疗中获益的慢性咳嗽患者。需要进一步的研究来确定FeNO在慢性咳嗽患者治疗中的诊断作用。