PDF(Pubmed)
Abstract：
Antibody obtained by the coronavirus disease-19 (COVID-19) mRNA vaccine declines over time, and additional vaccinations are offered. It is not clear how repeated vaccination affects humoral immunity in uninfected individuals. We analyzed immunoglobulin G for spike protein (S-IgG) titers in COVID-19 uninfected and infected individuals vaccinated up to six times. The geometric mean S-IgG titers were 575.9 AU/mL and 369.0 AU/mL in those who received 6 and 5 doses less than 180 days after the last vaccination in uninfected subjects. In the 180-360 days after the last vaccination, the geometric mean S-IgG titers were 237.9 AU/mL and 128.6 AU/mL in the uninfected subjects who underwent five-dose and four-dose groups, respectively. Multivariate analysis showed that S-IgG titer increased 1.261-fold with each additional dose of mRNA vaccine. The S-IgG titers were 2.039-fold higher in the COVID-infected subjects compared to uninfected subjects. The positivity rate of nucleocapsid antibodies, suggesting a history of COVID-19, decreased 82% and 30% of COVID-infected cases after 180 and 360 days of infection, respectively. This result suggested that repeated vaccination with the COVID-19 mRNA vaccine may increase antibody titer in uninfected subjects.
摘要：
冠状病毒病-19（COVID-19）疫苗获得的抗体mRNA随着时间的推移而下降，并提供额外的疫苗接种。目前尚不清楚重复接种疫苗如何影响未感染个体的体液免疫。我们分析了未感染和感染的COVID-19个体接种多达6次疫苗的免疫球蛋白G的刺突蛋白（S-IgG）滴度。在未感染的受试者中，在最后一次疫苗接种后不到180天接受6和5剂的那些人的几何平均S-IgG滴度为575.9AU/mL和369.0AU/mL。在最后一次接种疫苗后的180-360天内，在接受五剂量组和四剂量组的未感染受试者中，几何平均S-IgG滴度分别为237.9AU/mL和128.6AU/mL，分别。多变量分析显示，每增加一次mRNA疫苗，S-IgG滴度增加1.261倍。与未感染的受试者相比，感染COVID的受试者的S-IgG滴度高2.039倍。核衣壳抗体的阳性率，提示有COVID-19病史，在感染180天和360天后，减少了82%和30%的COVID感染病例，分别。这一结果表明，反复接种COVID-19mRNA疫苗可能会增加未感染受试者的抗体滴度。
