Abstract：
Mycotoxins frequently contaminate a variety of food items, posing significant concerns for both food safety and public health. The adverse consequences linked to poisoning from these substances encompass symptoms such as vomiting, loss of appetite, diarrhea, the potential for cancer development, impairments to the immune system, disruptions in neuroendocrine function, genetic damage, and, in severe cases, fatality. The deoxynivalenol (DON) raises significant concerns for both food safety and human health, particularly due to its potential harm to vital organs in the body. It is one of the most prevalent fungal contaminants found in edible items used by humans and animals globally. The presence of harmful mycotoxins, including DON, in food has caused widespread worry. Altered versions of DON have arisen as possible risks to the environment and well-being, as they exhibit a greater propensity to revert back to the original mycotoxins. This can result in the buildup of mycotoxins in both animals and humans, underscoring the pressing requirement for additional investigation into the adverse consequences of these modified mycotoxins. Furthermore, due to the lack of sufficient safety data, accurately evaluating the risk posed by modified mycotoxins remains challenging. Our review study delves into conjugated forms of DON, exploring its structure, toxicity, control strategies, and a novel animal model for assessing its toxicity. Various toxicities, such as acute, sub-acute, chronic, and cellular, are proposed as potential mechanisms contributing to the toxicity of conjugated forms of DON. Additionally, the study offers an overview of DON\'s toxicity mechanisms and discusses its widespread presence worldwide. A thorough exploration of the health risk evaluation associated with conjugated form of DON is also provided in this discussion.
摘要：
霉菌毒素经常污染各种食品，对食品安全和公共卫生都构成了重大关切。与这些物质中毒相关的不良后果包括呕吐等症状，食欲不振,腹泻,癌症发展的潜力，免疫系统受损，神经内分泌功能的破坏，遗传损伤,and,在严重的情况下，死亡。脱氧雪腐镰刀菌烯醇（DON）引起了人们对食品安全和人类健康的重大关注，特别是由于它对体内重要器官的潜在危害。它是在全球人类和动物使用的可食用物品中发现的最普遍的真菌污染物之一。有害真菌毒素的存在，包括DON,在食品中引起了广泛的担忧。DON的改变版本可能对环境和福祉构成风险，因为它们表现出更大的回归到原始真菌毒素的倾向。这可能导致真菌毒素在动物和人类中积累，强调迫切需要对这些修饰的霉菌毒素的不利后果进行进一步调查。此外，由于缺乏足够的安全数据，准确评估修饰的霉菌毒素所带来的风险仍然具有挑战性。我们的综述研究深入研究了DON的共轭形式，探索它的结构，毒性,控制策略,和评估其毒性的新型动物模型。各种毒性，如急性，亚急性,慢性，和细胞，被认为是导致DON缀合形式毒性的潜在机制。此外,该研究概述了DON的毒性机制，并讨论了其在全球范围内的广泛存在。本讨论还提供了与DON共轭形式相关的健康风险评估的彻底探索。
