PDF(Pubmed)
Abstract：
UNASSIGNED: Subjective cognitive decline (SCD) with a positive amyloid burden has been recognized as the earliest clinical symptom of the preclinical phase of Alzheimers disease (AD), providing invaluable opportunities to improve our understanding of the natural history of AD and determine strategies for early therapeutic interventions.
UNASSIGNED: The microstructure of white matter in patients showing SCD in the preclinical phase of AD (SCD of pre-AD) was evaluated using diffusion images, and voxel-wise fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities were assessed and compared among participant groups. Significant clusters in the tracts were extracted to determine their associations with alterations in the cognitive domains.
UNASSIGNED: We found that individuals with SCD of pre-AD may have subclinical episodic memory impairment associated with the global amyloid burden. Meanwhile, we found significantly reduced FA and λ1 in the right cingulum (cingulate and hippocampus) in AD dementia, while significantly increased FA and decreased MD as well as λ23 in the SCD of pre-AD group in comparison with the HC group.
UNASSIGNED: In conclusion, increased white matter microstructural integrity in the right cingulum (cingulate and hippocampus) may indicate compensation for short-term episodic memory in individuals with SCD of pre-AD in comparison with individuals with AD and healthy elderly individuals.
UNASSIGNED: The microstructure of white matter in patients showing SCD in the preclinical phase of AD (SCD of pre-AD) was evaluated using diffusion images, and voxel-wise fractional anisotropy (FA), mean diffusivity (MD), and axial and radial diffusivities were assessed and compared among participant groups. Significant clusters in the tracts were extracted to determine their associations with alterations in the cognitive domains.
UNASSIGNED: We found that individuals with SCD of pre-AD may have subclinical episodic memory impairment associated with the global amyloid burden. Meanwhile, we found significantly reduced FA and λ1 in the right cingulum (cingulate and hippocampus) in AD dementia, while significantly increased FA and decreased MD as well as λ23 in the SCD of pre-AD group in comparison with the HC group.
UNASSIGNED: In conclusion, increased white matter microstructural integrity in the right cingulum (cingulate and hippocampus) may indicate compensation for short-term episodic memory in individuals with SCD of pre-AD in comparison with individuals with AD and healthy elderly individuals.
摘要：
■具有阳性淀粉样蛋白负荷的主观认知功能下降（SCD）已被认为是阿尔茨海默氏病（AD）临床前期的最早临床症状，提供宝贵的机会，以提高我们对AD自然史的理解，并确定早期治疗干预的策略。
■使用扩散图像评估了在AD临床前阶段显示SCD（AD前的SCD）的患者白质的微观结构，和逐体素分数各向异性(FA)，平均扩散率（MD），在参与者组之间评估和比较轴向和径向扩散率。提取了片段中的重要聚类，以确定它们与认知领域变化的关联。
■我们发现，患有AD前期SCD的个体可能具有与整体淀粉样蛋白负荷相关的亚临床情节记忆障碍。同时,我们发现AD痴呆患者右侧扣带（扣带和海马）的FA和λ1显著降低，与HC组相比，AD前期组SCD的FA显着增加，MD和λ23降低。
■总而言之，与AD患者和健康老年人相比,右侧扣带(扣带和海马)的白质微结构完整性增加可能表明AD前期SCD患者对短期情景记忆的补偿.
■使用扩散图像评估了在AD临床前阶段显示SCD（AD前的SCD）的患者白质的微观结构，和逐体素分数各向异性(FA)，平均扩散率（MD），在参与者组之间评估和比较轴向和径向扩散率。提取了片段中的重要聚类，以确定它们与认知领域变化的关联。
■我们发现，患有AD前期SCD的个体可能具有与整体淀粉样蛋白负荷相关的亚临床情节记忆障碍。同时,我们发现AD痴呆患者右侧扣带（扣带和海马）的FA和λ1显著降低，与HC组相比，AD前期组SCD的FA显着增加，MD和λ23降低。
■总而言之，与AD患者和健康老年人相比,右侧扣带(扣带和海马)的白质微结构完整性增加可能表明AD前期SCD患者对短期情景记忆的补偿.
