UNASSIGNED: This is a retrospective, longitudinal, case-control study that included patients with NK, treated with rhNGF for at least 4 weeks, with pre- and post-treatment IVCM images available for analysis. Chart reviews were conducted documenting prior medical and surgical history, clinical signs and symptoms, and corneal sensation using Cochet-Bonnet esthesiometry. Corneal nerve parameters were assessed by IVCM. Sex- and age-matched reference controls were selected from a database of healthy subjects for comparison.
UNASSIGNED: The study included 25 patients, with 22 (88%) stage 1, two (8%) stage 2, and 1 (4%) stage 3 NK patients, with a median age of 64 years (range: 30-93 years). Total, main, and branch nerve densities [median (range) in mm/mm2] were lower in the NK group pre-treatment [2.3 (0.0-21.1); 1.7 (0.0-13.0); 0.5 (0.0-10.2); respectively] vs. controls [22.3 (14.9-29.0); 10.1 (3.2-15.4); and 12.1 (6.2-18.4), (p < 0.0001 for all), respectively]. Post-treatment nerve densities increased compared to pre-treatment to 5.3 (0.0-19.4, p = 0.0083) for total, 3.5 (0.0-13.2, p = 0.0059) for main, and 2.0 (0.0-10.4, p = 0.0251) for branch nerves, but remained lower than controls (p < 0.0001 for all). Corneal sensation increased from 2.3 ± 1.1 cm pre-treatment to 4.1 ± 1.4 cm post-treatment (p = 0.001). Median best corrected visual acuity significantly increased following rhNGF treatment from 0.4 (0.0-1.6) to 0.12 (-0.1 to 1.6) (p = 0.007).
UNASSIGNED: Patients with NK treated with at least 4 weeks of rhNGF, showed a significant increase in corneal nerve densities after treatment. A significant increase in corneal sensation, as well as best corrected visual acuity, was observed following treatment.
■这是一个回顾,纵向,包括NK患者的病例对照研究,用rhNGF治疗至少4周,治疗前和治疗后的IVCM图像可用于分析。进行了图表审查,记录了先前的医疗和手术史,临床症状和体征,和角膜感觉使用Cochet-Bonnet美学测量法。通过IVCM评估角膜神经参数。从健康受试者的数据库中选择性别和年龄匹配的参考对照用于比较。
■该研究包括25名患者,22例(88%)1期,2例(8%)2期和1例(4%)3期NK患者,年龄中位数为64岁(范围:30-93岁)。总计,主要,NK组治疗前[2.3(0.0-21.1);1.7(0.0-13.0);0.5(0.0-10.2);控制[22.3(14.9-29.0);10.1(3.2-15.4);和12.1(6.2-18.4),(所有p<0.0001),分别]。与治疗前相比,治疗后的神经密度增加至5.3(0.0-19.4,p=0.0083),3.5(0.0-13.2,p=0.0059),分支神经为2.0(0.0-10.4,p=0.0251),但仍低于对照组(全部p<0.0001)。角膜感觉从治疗前的2.3±1.1cm增加到治疗后的4.1±1.4cm(p=0.001)。rhNGF治疗后,最佳矫正视力中位数从0.4(0.0-1.6)显着增加到0.12(-0.1至1.6)(p=0.007)。
■接受至少4周rhNGF治疗的NK患者,显示治疗后角膜神经密度显着增加。角膜感觉显著增加,以及最佳矫正视力,治疗后观察到。