PDF(Pubmed)
Abstract：
BACKGROUND: Fibrous mediastinitis (FM) is a rare mediastinal lesion characterized by proliferation of fibrous tissue within the mediastinum. Previous reports have shown that this lesion can be caused by histoplasmosis and tuberculosis. In extremely rare cases, FM can also be caused by autoimmune diseases such as antineutrophil cytoplasmic antibody-associated vasculitis and large-vessel arteritis.
METHODS: In our case, we report unexpected fibrous mediastinitis found after robotic thymectomy in a patient with myasthenia gravis (MG). The preoperative imaging indicated no obvious lesion in the mediastinum and the patient denied histories of both histoplasmosis and tuberculosis. After the operation, both proliferation of fibrous tissue and ectopic germinal centres (GCs) could be found in the thymus.
CONCLUSIONS: This rare case might enrich our knowledge of the relationship between FM and autoimmune diseases.
METHODS: In our case, we report unexpected fibrous mediastinitis found after robotic thymectomy in a patient with myasthenia gravis (MG). The preoperative imaging indicated no obvious lesion in the mediastinum and the patient denied histories of both histoplasmosis and tuberculosis. After the operation, both proliferation of fibrous tissue and ectopic germinal centres (GCs) could be found in the thymus.
CONCLUSIONS: This rare case might enrich our knowledge of the relationship between FM and autoimmune diseases.
摘要：
背景：纤维纵隔炎（FM）是一种罕见的纵隔病变，其特征是纵隔内纤维组织增生。以前的报道表明，这种病变可能是由组织胞浆菌病和结核病引起的。在极少数情况下，FM也可由自身免疫性疾病如抗中性粒细胞胞浆抗体相关血管炎和大血管动脉炎引起。
方法：在我们的例子中，我们报道了一名重症肌无力(MG)患者在机器人胸腺切除术后发现的意外纤维性纵隔炎.术前影像学显示纵隔无明显病变，患者否认组织胞浆菌病和结核病史。手术后,在胸腺中可以发现纤维组织和异位生发中心（GC）的增殖。
结论：这一罕见病例可能丰富了我们对FM与自身免疫性疾病之间关系的认识。
方法：在我们的例子中，我们报道了一名重症肌无力(MG)患者在机器人胸腺切除术后发现的意外纤维性纵隔炎.术前影像学显示纵隔无明显病变，患者否认组织胞浆菌病和结核病史。手术后,在胸腺中可以发现纤维组织和异位生发中心（GC）的增殖。
结论：这一罕见病例可能丰富了我们对FM与自身免疫性疾病之间关系的认识。
