Abstract：
Preclinical dosimetry is essential for guiding the design of animal radiopharmaceutical biodistribution, imaging, and therapy experiments, evaluating efficacy and/or toxicities in such experiments, ensuring compliance with ethical standards for animal research, and, perhaps most importantly, providing reasonable initial estimates of normal-organ doses in humans, required for clinical translation of new radiopharmaceuticals. This MIB Guide provides a basic protocol for obtaining preclinical dosimetry estimates with organ-level dosimetry software.
摘要：
临床前剂量测定对于指导动物放射性药物生物分布的设计至关重要，成像,和治疗实验，在此类实验中评估功效和/或毒性，确保符合动物研究的道德标准，and,也许最重要的是,提供人类正常器官剂量的合理初步估计，临床翻译新放射性药物所需。本MIB指南提供了使用器官水平剂量测定软件获得临床前剂量测定估计的基本方案。
