Abstract：
Periodontitis is a bacterial-induced disease and for this reason controlling the microbiota is a necessity. Therapy includes self-performed daily oral hygiene in combination with supra- and sub-gingival instrumentation. An adjunctive antimicrobial agent may improve the outcome.
OBJECTIVE: To assess whether a chloramine (Perisolv®) has an adjunctive effect to non-surgical periodontal therapy and whether non-surgical periodontal therapy affects quality of life.
METHODS: Thirty-eight patients were randomized to a test or a control group. Clinical indices were performed at baseline and at three and twelve months. In the test group, Perisolv® was applied initially and after the sub-gingival instrumentation in pathological pockets. Oral health-related quality of life was measured with the Oral Health Impact Profile (OHIP) instrument at baseline and twelve months.
RESULTS: In both groups, an initial probing pocket depth (PPD) of > 4 mm and bleeding on probing (BOP) were statistically reduced (p < 0.002 and p < 0.002 respectively) at twelve months and after adjustment for Bonferroni. There were no significant differences between the test and the control group in terms of the number of PPD, BOP or plaque index, or in the mean OHIP score.
CONCLUSIONS: Chloramine did not have an adjunctive effect, but the overall therapy was significantly efficacious both clinically and in terms of quality of life.
BACKGROUND: Registered at www.
RESULTS: gov:NCT05757921.
OBJECTIVE: To assess whether a chloramine (Perisolv®) has an adjunctive effect to non-surgical periodontal therapy and whether non-surgical periodontal therapy affects quality of life.
METHODS: Thirty-eight patients were randomized to a test or a control group. Clinical indices were performed at baseline and at three and twelve months. In the test group, Perisolv® was applied initially and after the sub-gingival instrumentation in pathological pockets. Oral health-related quality of life was measured with the Oral Health Impact Profile (OHIP) instrument at baseline and twelve months.
RESULTS: In both groups, an initial probing pocket depth (PPD) of > 4 mm and bleeding on probing (BOP) were statistically reduced (p < 0.002 and p < 0.002 respectively) at twelve months and after adjustment for Bonferroni. There were no significant differences between the test and the control group in terms of the number of PPD, BOP or plaque index, or in the mean OHIP score.
CONCLUSIONS: Chloramine did not have an adjunctive effect, but the overall therapy was significantly efficacious both clinically and in terms of quality of life.
BACKGROUND: Registered at www.
RESULTS: gov:NCT05757921.
摘要：
牙周炎是一种细菌引起的疾病，因此必须控制微生物群。治疗包括自我执行的日常口腔卫生与牙龈上和牙龈下器械的组合。辅助抗微生物剂可以改善结果。
■评估氯胺（Perisolv®）是否对非手术牙周治疗具有辅助作用，以及非手术牙周治疗是否会影响生活质量。
■38名患者被随机分为试验组或对照组。在基线以及3个月和12个月时进行临床指标。在测试组中，最初和在病理性口袋中的牙龈下器械之后应用Perisolv®。在基线和12个月时，使用口腔健康影响概况（OHIP）仪器测量口腔健康相关的生活质量。
■在两组中，在校正Bonferroni后12个月,初始探查袋深度(PPD)>4mm,探查出血(BOP)在统计学上减少(分别为p<0.002和p<0.002).试验组与对照组在PPD数方面无显著性差异,防喷器或菌斑指数，或平均OHIP得分。
■氯胺没有辅助作用，但总体治疗在临床和生活质量方面均显著有效.
■在www注册。clinicaltrials.gov:NCT05757921。
■评估氯胺（Perisolv®）是否对非手术牙周治疗具有辅助作用，以及非手术牙周治疗是否会影响生活质量。
■38名患者被随机分为试验组或对照组。在基线以及3个月和12个月时进行临床指标。在测试组中，最初和在病理性口袋中的牙龈下器械之后应用Perisolv®。在基线和12个月时，使用口腔健康影响概况（OHIP）仪器测量口腔健康相关的生活质量。
■在两组中，在校正Bonferroni后12个月,初始探查袋深度(PPD)>4mm,探查出血(BOP)在统计学上减少(分别为p<0.002和p<0.002).试验组与对照组在PPD数方面无显著性差异,防喷器或菌斑指数，或平均OHIP得分。
■氯胺没有辅助作用，但总体治疗在临床和生活质量方面均显著有效.
■在www注册。clinicaltrials.gov:NCT05757921。
