This paper provides an in-depth analysis of NTM infections, including microbiology, environmental sources and transmission pathways, risk factors for disease, epidemiology, clinical manifestations and diagnostic approaches, guideline-based treatment recommendations, drugs under development, and management challenges.
Future approaches to the management of NTM pulmonary disease will require therapies that are well tolerated, can be taken for a shorter time period and perhaps less frequently, have few drug-drug interactions, and are active against the various strains of pathogens. As the numbers of infections increase, such therapies will be welcomed by clinicians and patients.
■本文对NTM感染进行了深入分析,包括微生物学,环境来源和传播途径,疾病的危险因素,流行病学,临床表现和诊断方法,基于指南的治疗建议,正在开发的药物,和管理挑战。
■NTM肺病的未来治疗方法将需要耐受性良好的治疗方法。可以在更短的时间内服用,也许频率更低,几乎没有药物相互作用,并且对各种病原体菌株具有活性。随着感染数量的增加,这种疗法将受到临床医生和患者的欢迎。