PDF(Pubmed)
Abstract：
Exercise-induced bronchoconstriction (EIB) is usually assessed by changes in forced expiratory volume in 1 s (FEV1 ) which is effort dependent. The purpose of this study was to determine whether the diaphragm electromyogram (EMGdi ) recorded from chest wall surface electrodes could be used to reflect changes in airway resistance during an exercise challenge test and to distinguish patients with EIB from those without EIB. Ninety participants with or without asthma history were included in the study. FEV1 was recorded before and 5, 10, 15, and 20 min after exercise. EIB was defined as an FEV1 decline greater than 10% after exercise. A ratio of root mean square of EMGdi to tidal volume (EMGdi /VT ) was used to assess changes in airway resistance. Based on changes in FEV1 , 25 of 90 participants exhibited EIB; the remainder were defined as non-EIB participants. EMGdi /VT in EIB increased by 124% (19%-478%) which was significantly higher than that of 21% (-39% to 134%) in non-EIB participants (p < 0.001). At the optimal cutoff point (54% in EMGdi /VT ), the area under the ROC curve (AUC) for detection of a positive test was 0.92 (p < 0.001) with sensitivity 92% and specificity 88%. EMGdi /VT can be used to assess changes in airway resistance after exercise and could be used to distinguish participants with EIB from those without EIB.
摘要：
运动诱发的支气管收缩（EIB）通常通过1s内用力呼气量（FEV1）的变化来评估，这是努力依赖性的。这项研究的目的是确定从胸壁表面电极记录的隔膜肌电图（EMGdi）是否可用于反映运动挑战测试期间气道阻力的变化，并区分患有EIB的患者和没有EIB的患者。90名有或没有哮喘病史的参与者被纳入研究。在运动前和运动后5、10、15和20分钟记录FEV1。EIB定义为运动后FEV1下降超过10%。使用EMGdi的均方根与潮气量的比率（EMGdi/VT）来评估气道阻力的变化。根据FEV1的变化，90名参与者中有25名表现出EIB；其余的被定义为非EIB参与者。EIB中的EMGdi/VT增加了124％（19％-478％），显着高于非EIB参与者的21％（-39％至134％）（p<0.001）。在最佳截止点(EMGdi/VT中为54%)，检测阳性试验的ROC曲线下面积(AUC)为0.92(p<0.001),敏感性为92%,特异性为88%.EMGdi/VT可用于评估运动后气道阻力的变化，并可用于区分EIB和无EIB的参与者。
