PDF(Pubmed)
Abstract：
BACKGROUND: Apical hypertrophic cardiomyopathy (ApHCM) is a phenotypic variant of hypertrophic cardiomyopathy. Endomyocardial fibrosis and endocardial calcification are especially rare in ApHCM.
METHODS: The main symptoms was chest tightness, palpitation, shortness of breath, and fatigue. Echocardiography and imaging examinations found apical hypertrophy along with endocardial calcification and endomyocardial fibrosis. Abnormal structural changes led to thrombosis and made the left ventricle a flat shape resembling an \"apple.\"
METHODS: The typical presentations, hypertrophic apex on echocardiography and an elevated N-terminal pro-brain natriuretic peptide level indicated the diagnosis of ApHCM and heart failure with preserved ejection fraction.
METHODS: Optimal medical therapy including the administration of ApHCM, heart failure and atrial fibrillation to improve symptoms and life quality.
RESULTS: Since discharge, the patient could perform normal daily activities and had no discomfort based on the optimal medical therapy.
CONCLUSIONS: We report a ApHCM patients with unusual presentations of endomyocardial fibrosis and apical calcification. This case highlights the importance of understanding the specific pathological changes of ApHCM for treatment and prognosis.
METHODS: The main symptoms was chest tightness, palpitation, shortness of breath, and fatigue. Echocardiography and imaging examinations found apical hypertrophy along with endocardial calcification and endomyocardial fibrosis. Abnormal structural changes led to thrombosis and made the left ventricle a flat shape resembling an \"apple.\"
METHODS: The typical presentations, hypertrophic apex on echocardiography and an elevated N-terminal pro-brain natriuretic peptide level indicated the diagnosis of ApHCM and heart failure with preserved ejection fraction.
METHODS: Optimal medical therapy including the administration of ApHCM, heart failure and atrial fibrillation to improve symptoms and life quality.
RESULTS: Since discharge, the patient could perform normal daily activities and had no discomfort based on the optimal medical therapy.
CONCLUSIONS: We report a ApHCM patients with unusual presentations of endomyocardial fibrosis and apical calcification. This case highlights the importance of understanding the specific pathological changes of ApHCM for treatment and prognosis.
摘要：
背景：心尖肥厚型心肌病（ApHCM）是肥厚型心肌病的一种表型变异。心内膜纤维化和心内膜钙化在ApHCM中尤其罕见。
方法：主要症状是胸闷，心悸,呼吸急促,和疲劳。超声心动图和影像学检查发现心尖肥大并伴有心内膜钙化和心内膜心肌纤维化。异常的结构变化导致血栓形成，并使左心室呈扁平形状，类似于“苹果”。\"
方法：典型演示文稿，超声心动图上的肥厚性顶点和升高的N末端脑钠肽前体水平表明诊断为ApHCM和射血分数保留的心力衰竭。
方法：最佳药物治疗，包括给予ApHCM，心力衰竭和心房颤动改善症状和生活质量。
结果：自出院以来，根据最佳药物治疗，患者可以进行正常的日常活动，并且没有不适。
结论：我们报告了一例ApHCM患者，其异常表现为心内膜心肌纤维化和心尖钙化。该病例强调了了解ApHCM的特定病理变化对治疗和预后的重要性。
方法：主要症状是胸闷，心悸,呼吸急促,和疲劳。超声心动图和影像学检查发现心尖肥大并伴有心内膜钙化和心内膜心肌纤维化。异常的结构变化导致血栓形成，并使左心室呈扁平形状，类似于“苹果”。\"
方法：典型演示文稿，超声心动图上的肥厚性顶点和升高的N末端脑钠肽前体水平表明诊断为ApHCM和射血分数保留的心力衰竭。
方法：最佳药物治疗，包括给予ApHCM，心力衰竭和心房颤动改善症状和生活质量。
结果：自出院以来，根据最佳药物治疗，患者可以进行正常的日常活动，并且没有不适。
结论：我们报告了一例ApHCM患者，其异常表现为心内膜心肌纤维化和心尖钙化。该病例强调了了解ApHCM的特定病理变化对治疗和预后的重要性。
