PDF(Pubmed)
Abstract：
The objective of this study was to examine the correlation between gut microbiota and both age-related macular degeneration (AMD) and glaucoma. Mendelian randomization studies were conducted utilizing the data sourced from the genome-wide association study (GWAS) database for the gut microbiome, AMD, and glaucoma. Single nucleotide polymorphism (SNP) estimates were summarized through five Mendelian randomization (MR) methods. We utilized Cochran\'s Q statistic to evaluate the heterogeneity of the instrumental variables (IVs). Additionally, we employed a \"leave-one-out\" approach to verify the stability of our findings. Inverse variance weighted (IVW) suggests that Eubacterium (oxidoreducens group) and Parabacteroides had a protective effect on AMD. Both weighted median and IVW suggest that Lachnospiraceae (NK4A136 group) and Ruminococcaceae (UCG009) had a protective effect on AMD. However, both weighted median and IVW suggest that Dorea had a risk effect on AMD. Similarly, The IVW of Eubacterium (ventriosum group) showed a risk effect on AMD. The weighted median of Eubacterium (nodatum group), Lachnospiraceae (NC2004 group), and Roseburia had a risk effect on glaucoma. IVW suggested that Ruminococcaceae (UCG004) had a risk effect on glaucoma. Reverse MR analysis found a causal link between Eubacterium (nodatum group) and glaucoma. No causal relationships were found between AMD or glaucoma and the other mentioned bacterial groups. No significant heterogeneity or evidence of horizontal pleiotropy was detected. This study found that certain gut bacteria had protective effects on AMD, while others may be risk factors for AMD or glaucoma. Likewise, reverse MR found that glaucoma led to an increased abundance of certain gut bacteria. Further trials are needed to clarify the specific mechanisms involved.
摘要：
这项研究的目的是检查肠道微生物群与年龄相关性黄斑变性（AMD）和青光眼之间的相关性。孟德尔随机化研究是利用来自肠道微生物组的全基因组关联研究（GWAS）数据库的数据进行的。AMD,和青光眼。通过五种孟德尔随机化（MR）方法总结了单核苷酸多态性（SNP）估计。我们利用Cochran的Q统计量来评估工具变量(IV)的异质性。此外,我们采用了“留一法”方法来验证我们研究结果的稳定性。反向方差加权（IVW）表明真细菌（氧化还原组）和副细菌对AMD具有保护作用。加权中位数和IVW均表明Lachnospirosaceae（NK4A136组）和Ruminoccaceae（UCG009）对AMD具有保护作用。然而,加权中位数和IVW均提示Dorea对AMD有风险影响.同样，Eubacterium(ventriosum组)的IVW对AMD显示出风险效应。真杆菌的加权中位数(nodatum组)，落叶松科（NC2004组），和Roseburia对青光眼有风险影响。IVW表明，Ruminococycaceae（UCG004）对青光眼有风险作用。反向MR分析发现Eubacterium（nodatum组）与青光眼之间存在因果关系。在AMD或青光眼与其他提及的细菌组之间未发现因果关系。未检测到显着的异质性或水平多效性的证据。这项研究发现，某些肠道细菌对AMD有保护作用，而其他可能是AMD或青光眼的危险因素。同样，反向MR发现青光眼导致某些肠道细菌的丰度增加.需要进一步的试验来澄清所涉及的具体机制。
