PDF(Pubmed)
Abstract：
This retrospective study aimed to investigate the impact of microorganisms identified in the reproductive tract on disorders during the early adaptation period in newborns. A cohort of 823 patients and cervical canal cultures were analyzed to identify the presence of microorganisms. Newborns included in the study were divided into two groups due to the number of pathogens identified in the swab from the cervical canal of the mother. The first group consisted of newborns whose mothers had one pathogen identified (N = 637), while the second group consisted of newborns whose mothers had two or more pathogens identified (N = 186). The analysis of disorders of the early adaptation period included the incidence of respiratory distress syndrome, the number of procedures performed with the use of CPAP, oxygen therapy, antibiotic therapy and parenteral nutrition. Respiratory distress syndrome was more common in group II than in group I (85 vs. 31, p = 0.001). In group II, CPAP (63 vs. 21, p = 0.001), oxygen therapy (15 vs. 8, p = 0.02) and antibiotics were used more frequently (13 vs. 8, p = 0.01). The findings of this study revealed that the number of pathogens colonizing the reproductive tract had a significant influence on the early adaptation period in newborns. Multifactorial colonization of the reproductive tract was associated with an increased incidence of infections in newborns and a higher prevalence of acid-base balance disorders. This study highlights the importance of monitoring and addressing the microbial composition of the reproductive tract during pregnancy.
摘要：
这项回顾性研究旨在调查生殖道中鉴定的微生物对新生儿早期适应期疾病的影响。对823名患者和宫颈管培养物进行了分析，以鉴定微生物的存在。由于从母亲宫颈管的拭子中鉴定出的病原体数量，该研究中包括的新生儿分为两组。第一组由新生儿组成，其母亲有一种病原体（N=637），而第二组由母亲发现两种或两种以上病原体的新生儿组成(N=186)。早期适应期疾病的分析包括呼吸窘迫综合征的发生率，使用CPAP执行的程序数量，氧疗,抗生素治疗和肠外营养。Ⅱ组比Ⅰ组更常见呼吸窘迫综合征（85vs.31，p=0.001）。在第二组中，CPAP（63vs.21，p=0.001），氧疗（15vs.8，p=0.02），抗生素的使用频率更高（13vs.8,p=0.01)。这项研究的结果表明，生殖道定植的病原体数量对新生儿的早期适应期有显着影响。生殖道的多因素定植与新生儿感染发生率增加和酸碱平衡障碍患病率升高有关。这项研究强调了监测和解决怀孕期间生殖道微生物组成的重要性。
