Abstract：
This study aimed to validate the proposed Korean Working Group on Sarcopenia (KWGS) guideline, which introduces the concept of functional sarcopenia, in older Korean adults.
Data from the Aging Study of Pyeongchang Rural Area, a longitudinal cohort of community-dwelling older adults, were utilized to compare frailty status and institutionalization-free survival among participants according to sarcopenia status. Based on the KWGS guideline, severe sarcopenia was defined as low muscle mass and strength with slow gait speed; sarcopenia (not severe) was defined as low muscle mass with low muscle strength or slow gait speed; and functional sarcopenia was defined as low muscle strength and slow gait speed without low muscle mass.
Among the 1302 participants, 329 (25.3 %) had severe sarcopenia, 147 (11.3 %) had sarcopenia (not severe), and 277 (21.3 %) had functional sarcopenia. Frailty was significantly greater in participants with any phenotype of sarcopenia than in those without sarcopenia. Additionally, participants with functional sarcopenia were frailer than those with sarcopenia (not severe). Furthermore, the rates of institutionalization and mortality were higher in participants with any phenotype of sarcopenia than in those without sarcopenia. There was no statistical difference between the rates of sarcopenia (not severe) and those with functional sarcopenia. These findings remained consistent after adjusting for age and sex.
Each phenotype according to the KWGS guideline was associated with significantly greater frailty and increased risk of institutionalization and mortality. Functional sarcopenia was associated with greater frailty and had comparable prognosis with sarcopenia (not severe).
Data from the Aging Study of Pyeongchang Rural Area, a longitudinal cohort of community-dwelling older adults, were utilized to compare frailty status and institutionalization-free survival among participants according to sarcopenia status. Based on the KWGS guideline, severe sarcopenia was defined as low muscle mass and strength with slow gait speed; sarcopenia (not severe) was defined as low muscle mass with low muscle strength or slow gait speed; and functional sarcopenia was defined as low muscle strength and slow gait speed without low muscle mass.
Among the 1302 participants, 329 (25.3 %) had severe sarcopenia, 147 (11.3 %) had sarcopenia (not severe), and 277 (21.3 %) had functional sarcopenia. Frailty was significantly greater in participants with any phenotype of sarcopenia than in those without sarcopenia. Additionally, participants with functional sarcopenia were frailer than those with sarcopenia (not severe). Furthermore, the rates of institutionalization and mortality were higher in participants with any phenotype of sarcopenia than in those without sarcopenia. There was no statistical difference between the rates of sarcopenia (not severe) and those with functional sarcopenia. These findings remained consistent after adjusting for age and sex.
Each phenotype according to the KWGS guideline was associated with significantly greater frailty and increased risk of institutionalization and mortality. Functional sarcopenia was associated with greater frailty and had comparable prognosis with sarcopenia (not severe).
摘要：
背景：这项研究旨在验证拟议的韩国肌肉减少症工作组（KWGS）指南，其中引入了功能性肌少症的概念，在韩国老年人中。
方法：来自平昌农村地区老龄化研究的数据，社区居住的老年人的纵向队列，根据肌肉减少症状态，用于比较参与者的虚弱状态和无制度化生存。根据KWGS准则,严重的肌肉减少症定义为肌肉质量和力量低,步态速度慢;肌肉减少症(不严重)定义为肌肉质量低,肌肉强度低或步态速度慢;功能性肌肉减少症定义为肌肉强度低,步态速度慢,肌肉质量低.
结果：在1302名参与者中，329人（25.3%）患有严重的肌肉减少症，147人（11.3%）患有肌肉减少症（非严重），277例(21.3%)患有功能性肌少症。患有任何肌肉减少症表型的参与者的虚弱程度明显高于没有肌肉减少症的参与者。此外,患有功能性肌少症的参与者比患有肌少症的参与者更虚弱(非严重).此外，有任何肌少症表型的参与者的住院率和死亡率均高于无肌少症的参与者.肌肉减少症（非严重）和功能性肌肉减少症的发生率之间没有统计学差异。在调整了年龄和性别后，这些发现仍然是一致的。
结论：根据KWGS指南，每个表型与显著更大的虚弱和增加的住院风险和死亡率相关。功能性少肌症与更大的虚弱相关，预后与少肌症（不严重）相当。
方法：来自平昌农村地区老龄化研究的数据，社区居住的老年人的纵向队列，根据肌肉减少症状态，用于比较参与者的虚弱状态和无制度化生存。根据KWGS准则,严重的肌肉减少症定义为肌肉质量和力量低,步态速度慢;肌肉减少症(不严重)定义为肌肉质量低,肌肉强度低或步态速度慢;功能性肌肉减少症定义为肌肉强度低,步态速度慢,肌肉质量低.
结果：在1302名参与者中，329人（25.3%）患有严重的肌肉减少症，147人（11.3%）患有肌肉减少症（非严重），277例(21.3%)患有功能性肌少症。患有任何肌肉减少症表型的参与者的虚弱程度明显高于没有肌肉减少症的参与者。此外,患有功能性肌少症的参与者比患有肌少症的参与者更虚弱(非严重).此外，有任何肌少症表型的参与者的住院率和死亡率均高于无肌少症的参与者.肌肉减少症（非严重）和功能性肌肉减少症的发生率之间没有统计学差异。在调整了年龄和性别后，这些发现仍然是一致的。
结论：根据KWGS指南，每个表型与显著更大的虚弱和增加的住院风险和死亡率相关。功能性少肌症与更大的虚弱相关，预后与少肌症（不严重）相当。
