PDF(Pubmed)
Abstract：
Muco-obstructive lung disease is a new classification under the diseases of respiratory tract. A lot of discussion is still going on regarding this new group of diseases. It is characterised by obstruction of the respiratory tract with a thick mucin layer. Usually in normal individuals, the mucus is swept out of the respiratory system while coughing in the form of sputum or phlegm, but if the consistency of the mucus is thick, or the amount is heavy or there is a certain defect in the ciliary function of the respiratory tract, the mucus is not cleared and it gets accumulated in the lungs alveoli, therefore blocking it. The mucus trapped in the distal airways cannot be cleared by coughing therefore forming a layer in the alveoli and bronchioles. Long-standing condition causes inflammation and infection. This new group of diseases specifically includes chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and non-cystic fibrosis bronchiectasis (NCFB). Asthma, although an obstructive disease of the lung, is not particularly included under muco-obstructive lung disease. The major symptoms with which these diseases present are sputum production, chronic cough and acute exacerbations of the condition. The mucus adheres to the lung parenchyma causing airway obstruction and hyperinflation. In this article, we will see how muco-obstructive lung diseases affect the normal physiology of the respiratory system and how is it different from other obstructive and restrictive lung diseases. We will individually look into all the four conditions that come under the category of muco-obstructive lung diseases.
摘要：
阻塞性肺疾病是呼吸道疾病的新分类。关于这种新疾病的讨论仍在进行中。其特征是呼吸道阻塞有厚厚的粘蛋白层。通常在正常人中，粘液以痰或痰的形式咳嗽时被排出呼吸系统，但是如果粘液的稠度很厚，或数量沉重或呼吸道纤毛功能有一定缺陷，粘液没有被清除，它积聚在肺泡中，因此阻止它。滞留在远端气道中的粘液不能通过咳嗽清除,因此在肺泡和细支气管中形成一层。长期状况会导致炎症和感染。这组新的疾病特别包括慢性阻塞性肺疾病（COPD），囊性纤维化（CF），原发性纤毛运动障碍（PCD）和非囊性纤维化支气管扩张（NCFB）。哮喘,虽然是肺部的阻塞性疾病,不特别包括在粘膜阻塞性肺病下。这些疾病的主要症状是痰液的产生，慢性咳嗽和急性加重。粘液粘附在肺实质上，导致气道阻塞和过度膨胀。在这篇文章中,我们将看到粘液阻塞性肺病如何影响呼吸系统的正常生理，以及它与其他阻塞性和限制性肺病有何不同。我们将单独研究粘膜阻塞性肺病类别下的所有四种疾病。
