Abstract：
BACKGROUND: Activated platelets exert a key role in the pathogenesis of preeclampsia (PE). There is evidence of distinctive patterns of platelet indices in PE in comparison to healthy pregnancies, therefore these indices can be potential tools for PE detection, risk stratification, and management. Considering the vascular aspects of its pathophysiology, PE is characterized by the increased levels of soluble FMS-like tyrosine kinase-1 (sFlt-1) an antiangiogenic factor, and reduced placental growth factor (PlGF), a proangiogenic factor. This study aimed to assess the platelet indices in hypertensive disorders of pregnancy (HDP) and its correlation with angiogenesis-related biomarkers.
METHODS: The groups for the study were: control (n = 114); gestational hypertension; (n = 112), and PE (n = 42). The platelet indices included were platelet counts (PLT-I and PLT-F), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet large cell ratio (P-LCR), and immature platelet fraction (IPF# and IPF%). Serum levels of sFlt-1 and PlGF were assessed.
RESULTS: PLT-I, PLT-F, and PCT% were lower in PE, while MPV, PDW, P-LCR, IPF%, and IPF# were increased. The parameter MPV presented the best performance for the discrimination of PE. There was a moderate positive correlation between sFlt-1 levels and MPV, PDW, and P-LCR.
CONCLUSIONS: Platelet indices can be potentially applied as additional tools for the diagnosis and management of HDP. Activated platelets may act as an extra source of sFlt-1 in PE.
METHODS: The groups for the study were: control (n = 114); gestational hypertension; (n = 112), and PE (n = 42). The platelet indices included were platelet counts (PLT-I and PLT-F), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet large cell ratio (P-LCR), and immature platelet fraction (IPF# and IPF%). Serum levels of sFlt-1 and PlGF were assessed.
RESULTS: PLT-I, PLT-F, and PCT% were lower in PE, while MPV, PDW, P-LCR, IPF%, and IPF# were increased. The parameter MPV presented the best performance for the discrimination of PE. There was a moderate positive correlation between sFlt-1 levels and MPV, PDW, and P-LCR.
CONCLUSIONS: Platelet indices can be potentially applied as additional tools for the diagnosis and management of HDP. Activated platelets may act as an extra source of sFlt-1 in PE.
摘要：
背景：活化的血小板在先兆子痫（PE）的发病机理中发挥关键作用。与健康妊娠相比，有证据表明PE中血小板指数的独特模式，因此，这些指标可以成为PE检测的潜在工具，风险分层，和管理。考虑到其病理生理学的血管方面，PE的特征在于可溶性FMS样酪氨酸激酶-1（sFlt-1）的水平增加，一种抗血管生成因子，和减少胎盘生长因子（PlGF），促血管生成因子.本研究旨在评估妊娠高血压疾病（HDP）的血小板指标及其与血管生成相关生物标志物的相关性。
方法：研究组为：对照组（n=114）；妊娠期高血压；（n=112），和PE（n=42）。纳入的血小板指标为血小板计数(PLT-I和PLT-F),平均血小板体积（MPV），血小板分布宽度（PDW），plateletcrit（PCT），血小板大细胞比率（P-LCR），和未成熟的血小板分数(IPF#和IPF%)。评估sFlt-1和PlGF的血清水平。
结果：PLT-I，PLT-F,PE和PCT%较低，而MPV,PDW,P-LCR,IPF%,IPF#增加。参数MPV为PE的辨别提供了最佳性能。sFlt-1水平与MPV呈中度正相关,PDW,P-LCR
结论：血小板指数可作为诊断和治疗HDP的额外工具。活化的血小板可以作为PE中sFlt-1的额外来源。
方法：研究组为：对照组（n=114）；妊娠期高血压；（n=112），和PE（n=42）。纳入的血小板指标为血小板计数(PLT-I和PLT-F),平均血小板体积（MPV），血小板分布宽度（PDW），plateletcrit（PCT），血小板大细胞比率（P-LCR），和未成熟的血小板分数(IPF#和IPF%)。评估sFlt-1和PlGF的血清水平。
结果：PLT-I，PLT-F,PE和PCT%较低，而MPV,PDW,P-LCR,IPF%,IPF#增加。参数MPV为PE的辨别提供了最佳性能。sFlt-1水平与MPV呈中度正相关,PDW,P-LCR
结论：血小板指数可作为诊断和治疗HDP的额外工具。活化的血小板可以作为PE中sFlt-1的额外来源。
