关键词: Bone pain CNO CRMO Chronic recurrent multifocal osteomyelitis Whole-body MRI

Mesh : Humans Osteomyelitis / diagnostic imaging drug therapy Diphosphonates / therapeutic use Magnetic Resonance Imaging Chronic Disease

来  源:   DOI:10.1016/j.mcna.2023.05.022

Abstract:
Chronic recurrent multifocal osteomyelitis (CRMO) is an underrecognized autoinflammatory disease affecting the skeletal system. Its vague symptoms are often first attributed to growing pains, infection, or malignancy, which can lead to a delay in diagnosis for days to years. Untreated CRMO has the potential to cause debilitating skeletal deformities, arthritis, and chronic pain; hence early recognition and treatment are paramount. MRI is the gold standard for diagnosis. Treatment consists of various antiinflammatory medications and may also include bisphosphonates if vulnerable skeletal sites are involved. Even when treated, the disease may have a relapsing course lasting years.
摘要:
慢性复发性多灶性骨髓炎(CRMO)是一种未被认识到的影响骨骼系统的自身炎性疾病。它模糊的症状通常首先归因于成长的痛苦,感染,或者恶性肿瘤,这可能会导致诊断延迟几天到几年。未经治疗的CRMO有可能导致使人衰弱的骨骼畸形,关节炎,和慢性疼痛;因此早期识别和治疗是至关重要的。MRI是诊断的金标准。治疗包括各种抗炎药,如果涉及脆弱的骨骼部位,也可以包括双膦酸盐。即使经过治疗,这种疾病可能会有持续数年的复发过程。
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