PDF(Pubmed)
Abstract：
OBJECTIVE: Hepatitis B virus (HBV) is a leading causative agent of viral hepatitis. A preventative vaccine has existed for decades, but only limited treatment options are available for people living with chronic HBV. Animal models for studying HBV are constrained due to narrow viral tropism, impeding understanding of the natural immune response to the virus. Here, using a vector to overcome the narrow host range and establish HBV replication in mice, we identified the role of helper T cells in controlling HBV. We show that helper T cells promote the B cell\'s ability to generate antibodies that remove HBV and its associated surface antigen from the blood and that transfer of purified helper T cells from HBV-immunized mice can reverse the accumulation of virus and antigen, furthering our understanding of the immune response to HBV.
摘要：
目的：乙型肝炎病毒（HBV）是病毒性肝炎的主要病原体。预防性疫苗已经存在了几十年，但只有有限的治疗选择可用于患有慢性HBV的人。用于研究HBV的动物模型由于狭窄的病毒嗜性而受到限制，阻碍对病毒自然免疫反应的理解。这里,使用载体来克服狭窄的宿主范围，并在小鼠中建立HBV复制，我们确定了辅助性T细胞在控制HBV中的作用。我们表明，辅助性T细胞促进B细胞产生抗体的能力，从血液中去除HBV及其相关的表面抗原，从HBV免疫小鼠中转移纯化的辅助性T细胞可以逆转病毒和抗原的积累，进一步了解HBV的免疫反应。
