Abstract：
By synergistically employing four key strategies: (I) introducing tetraphenylethylene groups as the central core unit with aggregation-induced emission (AIE) properties, (II) optimizing the π-conjugated length by extending the building block branches, (III) incorporating flexible groups containing ethylenic bonds, and (IV) applying crystal engineering to attain dense stacking mode and highly twisty conformation, we successfully synthesized a series of hydrogen-bonded organic frameworks (HOFs) exhibiting exceptional one/two-photon excited fluorescence. Notably, when utilizing the fluorescently superior building block L2, HOF-LIFM-7 and HOF-LIFM-8 exhibiting high quantum yields (QY) of 82.1 % and 77.1 %, and ultrahigh two-photon absorption (TPA) cross-sections of 148959.5 GM and 123901.1 GM were achieved. These materials were successfully employed in one and two-photon excited lysosome-targeting cellular imaging. It is believed that this strategy, combining building block optimization and crystal engineering, holds significant potential for guiding the development of outstanding fluorescent HOF materials.
摘要：
通过协同采用四个关键策略：（I）引入四苯基乙烯基团作为具有聚集诱导发射（AIE）特性的中心核心单元，（II）通过扩展积木分支来优化π共轭长度，(三)加入含有烯键的柔性基团，(四)应用晶体工程实现密集堆积模式和高度扭曲构象，我们成功地合成了一系列表现出单/双光子激发荧光的氢键有机骨架（HOFs）。值得注意的是,当使用荧光优越的构建块L2时，HOF-LIFM-7和HOF-LIFM-8表现出82.1％和77.1％的高量子产率（QY），并实现了148959.5GM和123901.1GM的超高双光子吸收（TPA）截面。这些材料已成功用于单光子和双光子激发的溶酶体靶向细胞成像。相信这一战略,积木优化与水晶工程相结合,具有指导杰出的荧光HOF材料发展的巨大潜力。
