PDF(Pubmed)
Abstract：
The purpose of this systematic review was to analyze the current use of adipose-derived mesenchymal stem cells (ADMSCs) and present the available evidence on their therapeutic potential in the treatment of ankle orthopedic issues, evaluating the applications and results. A literature search of PubMed, Google Scholar, EMBASE and Cochrane Library database was performed. The review was conducted following PRISMA guidelines. Risk of bias assessment was conducted through the Methodological Index for Non-Randomized Studies (MINORS) criteria. Initial search results yielded 4348 articles. A total of 8 articles were included in the review process. No clinical evidence has demonstrated the effectiveness of one isolation method over the other, but nonenzymatic mechanical method has more advantages. In all studies included significant clinical outcomes improvement were recorded in patients affected by osteochondral lesion and osteoarthritis of ankle. All studies performed a concomitant procedure. No serious complications were reported. ADMSC injection, especially through the nonenzymatic mechanical methods, looks to be simple and promising treatment for osteochondral lesions and osteoarthritis of the ankle, with no severe complications. The current scarcity of studies and their low-quality level preclude definitive conclusions presently. LEVEL OF EVIDENCE: III.
摘要：
本系统综述的目的是分析脂肪间充质干细胞（ADMSCs）的当前用途，并提出其在踝关节矫形问题治疗中的治疗潜力的现有证据。评估应用和结果。PubMed的文献检索，谷歌学者，进行EMBASE和Cochrane库数据库。审查是根据PRISMA指南进行的。偏倚风险评估通过非随机研究方法学指数（MINORS）标准进行。初步搜索结果产生了4348篇文章。共有8篇文章被纳入审查过程。没有临床证据证明一种分离方法比另一种方法有效，但非酶机械法更具优势。在所有研究中，受骨软骨损伤和踝关节骨性关节炎影响的患者均记录到显着的临床结果改善。所有研究都进行了伴随程序。无严重并发症报告。ADMSC注射,特别是通过非酶机械方法，对于骨软骨病变和踝关节骨性关节炎,无严重并发症。当前研究的稀缺性及其低质量水平目前无法得出明确的结论。证据级别：III.
