Abstract：
Coronary heart disease (CHD) confers a high risk of cognitive and mental impairments in patients. This study aimed to explore the association of CHD with functional connectivity and topological properties of brain networks. A total of 27 patients with CHD and 44 healthy controls (HCs) participated in this study and underwent a resting-state functional magnetic resonance imaging (rs-fMRI) scan. Intra- and internetwork functional connectivity alterations were explored using independent component analysis in CHD patients. Furthermore, graph theoretical analysis was adopted to assess abnormalities in small-world properties and network efficiency metrics of brain networks. Compared to HCs, CHD patients exhibited increased functional connectivity between the posterior default mode network and posterior visual network, as well as decreased functional connectivity between the left frontoparietal network and auditory network. In terms of graph theoretical analysis, small-world network topology was identified in both CHD patients and HCs. Furthermore, the nodal local efficiency of the left putamen was significantly decreased in CHD patients compared to HCs. This study revealed alterations in brain functional connectivity and topological properties in CHD patients, shedding light on the potential neurological mechanism underlying cognitive and mental impairments in these patients and suggesting unexplored connections between CHD and higher order cognitive processing.
摘要：
冠心病（CHD）赋予患者认知和精神障碍的高风险。本研究旨在探讨CHD与脑网络的功能连通性和拓扑特性的关系。共有27名CHD患者和44名健康对照（HCs）参加了这项研究，并进行了静息状态功能磁共振成像（rs-fMRI）扫描。在CHD患者中使用独立成分分析探索网络内和网络间功能连接改变。此外，采用图论分析来评估脑网络的小世界属性和网络效率指标的异常。与HC相比，CHD患者后默认模式网络和后视觉网络之间的功能连通性增加，以及左额顶网络和听觉网络之间的功能连通性降低。在图论分析方面，在CHD患者和HCs中均发现了小世界网络拓扑.此外，与HC相比,CHD患者左壳核的淋巴结局部效率显著降低.这项研究揭示了CHD患者脑功能连通性和拓扑特性的改变，阐明这些患者认知和精神障碍潜在的神经机制，并提示CHD与高阶认知过程之间未探索的联系。
