PDF(Pubmed)
Abstract：
Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH), a rare disease previously overlooked, is gradually being recognized as an important precursor state to pulmonary neuroendocrine tumors. The very insidious onset of symptom presentation makes early diagnosis of DIPNECH almost impossible in clinical settings. In this report, we present a case of persistent and worsening cough for over five years with waxing and waning lung nodules of varying sizes which were eventually diagnosed as DIPNECH on biopsy. However, due to the location and the multiplicity of these nodules, surgical resection was not an option in this case. The diagnostic workup including imaging and biopsy, management options, and possible prognosis of DIPNECH are discussed in detail. This report highlights the growing recognition of DIPNECH as a clinical entity to be aware of during the formulation of a differential diagnosis for patients presenting with chronic unrelenting cough and associated lung nodules.
摘要：
弥漫性特发性肺神经内分泌细胞增生(DIPNECH),一种以前被忽视的罕见疾病，逐渐被认为是肺神经内分泌肿瘤的重要前兆状态。症状表现的非常阴险的发作使得DIPNECH的早期诊断在临床上几乎是不可能的。在这份报告中,我们介绍了一例持续且恶化的咳嗽超过5年的病例,伴有不同大小的打蜡和脱落的肺结节,最终在活检中被诊断为DIPNECH.然而,由于这些结节的位置和多样性，在这种情况下,手术切除不是一种选择.诊断检查包括成像和活检，管理选项，并详细讨论了DIPNECH的可能预后。本报告强调了DIPNECH作为一种临床实体的认识，在为表现为慢性持续咳嗽和相关肺结节的患者制定鉴别诊断的过程中，应注意。
