PDF(Pubmed)
Abstract：
UNASSIGNED: Cancer-associated thrombosis (CAT) is one of the major complications during the treatment course of cancer, which often challenges clinicians in daily clinical practice despite anticoagulation therapy.
UNASSIGNED: A 57-year-old man with a history of a liver transplantation was diagnosed with post-transplant lymphoproliferative disorders. He developed severe systemic thromboses including a massive pulmonary embolism and was treated with anticoagulation therapy including a factor Xa inhibitor. However, the systemic thromboses worsened despite the anticoagulation therapy. During the acute treatment course of the thromboses, we administered anticancer drug therapy in hopes of an improvement in the activity of the cancer status leading to a favourable effect on the thrombosis status. Multi-disciplinary treatment including anticoagulation therapy and anticancer drug therapy successfully improved the systemic thrombosis.
UNASSIGNED: Anticoagulation therapy is a standard treatment for CAT; however, some cases of CAT do not successfully improve despite anticoagulation therapy, partly due to a highly active cancer status. Anticancer drug therapy might increase the risk of a thrombosis, whereas it could improve the activity of the cancer status leading to a decreased risk of a thrombosis. A multi-disciplinary therapy might be a reasonable option especially for CAT with a highly active cancer status.
UNASSIGNED: A 57-year-old man with a history of a liver transplantation was diagnosed with post-transplant lymphoproliferative disorders. He developed severe systemic thromboses including a massive pulmonary embolism and was treated with anticoagulation therapy including a factor Xa inhibitor. However, the systemic thromboses worsened despite the anticoagulation therapy. During the acute treatment course of the thromboses, we administered anticancer drug therapy in hopes of an improvement in the activity of the cancer status leading to a favourable effect on the thrombosis status. Multi-disciplinary treatment including anticoagulation therapy and anticancer drug therapy successfully improved the systemic thrombosis.
UNASSIGNED: Anticoagulation therapy is a standard treatment for CAT; however, some cases of CAT do not successfully improve despite anticoagulation therapy, partly due to a highly active cancer status. Anticancer drug therapy might increase the risk of a thrombosis, whereas it could improve the activity of the cancer status leading to a decreased risk of a thrombosis. A multi-disciplinary therapy might be a reasonable option especially for CAT with a highly active cancer status.
摘要：
■癌症相关血栓形成(CAT)是癌症治疗过程中的主要并发症之一,尽管接受了抗凝治疗，但临床医生在日常临床实践中经常面临挑战。
■一名57岁有肝移植史的男子被诊断为移植后淋巴增生性疾病。他出现了严重的全身性血栓形成，包括大面积肺栓塞，并接受了包括Xa因子抑制剂在内的抗凝治疗。然而,尽管抗凝治疗,但全身性血栓恶化.在血栓形成的急性治疗过程中，我们给予抗癌药物治疗，以期改善癌症状态的活性，从而对血栓形成状态产生有利影响。包括抗凝治疗和抗癌药物治疗在内的多学科治疗成功改善了全身血栓形成。
■抗凝治疗是CAT的标准治疗方法；然而，尽管抗凝治疗，一些CAT病例仍未成功改善，部分原因是高度活跃的癌症状态。抗癌药物治疗可能会增加血栓形成的风险，而它可以改善癌症状态的活性，从而降低血栓形成的风险。多学科治疗可能是一个合理的选择，特别是对于具有高度活跃癌症状态的CAT。
■一名57岁有肝移植史的男子被诊断为移植后淋巴增生性疾病。他出现了严重的全身性血栓形成，包括大面积肺栓塞，并接受了包括Xa因子抑制剂在内的抗凝治疗。然而,尽管抗凝治疗,但全身性血栓恶化.在血栓形成的急性治疗过程中，我们给予抗癌药物治疗，以期改善癌症状态的活性，从而对血栓形成状态产生有利影响。包括抗凝治疗和抗癌药物治疗在内的多学科治疗成功改善了全身血栓形成。
■抗凝治疗是CAT的标准治疗方法；然而，尽管抗凝治疗，一些CAT病例仍未成功改善，部分原因是高度活跃的癌症状态。抗癌药物治疗可能会增加血栓形成的风险，而它可以改善癌症状态的活性，从而降低血栓形成的风险。多学科治疗可能是一个合理的选择，特别是对于具有高度活跃癌症状态的CAT。
