PDF(Pubmed)
Abstract：
Several data have suggested that pregnant women have an increased risk of severe COVID-19 compared to those who are not pregnant. Moreover, different studies have showed that severe COVID-19 is limited mostly to unvaccinated women. The aim of the present study was to ascertain the different maternal and fetal outcomes in pregnant women with COVID-19 according to their vaccination status. A retrospective cohort study was carried out including all women admitted to the high-risk pregnancy unit of our center with COVID-19 between December 2021 and February 2022. Among the 163 women included in the study, 60 were vaccinated with an mRNA vaccine and 103 were unvaccinated. Pregnancy outcome and obstetrical and neonatal complications were encountered. Vaccinated women showed higher educational levels and lower prevalence of cases, with BMI >25 compared to unvaccinated women. Moreover, vaccinated women were admitted mostly for obstetrical indications rather than for COVID-related symptoms. In addition, the risk of developing COVID-19 pneumonia was significantly higher in unvaccinated women (p = 0.01) compared with vaccinated ones. Furthermore, pregnancy and neonatal outcomes showed some differences in the two cohorts. In unvaccinated women, the rate of C-section was higher (p = 0.03), and the mean birthweight percentile in their infants was impaired by COVID-19 infection (p = 0.01) when compared to those born to vaccinated women. Based on these results, we suggest that women who received a full course of vaccination were protected from the severity of the disease, having milder symptoms of SARS-Cov2 infection, while also presenting a more favorable pregnancy outcome.
摘要：
一些数据表明，与未怀孕的孕妇相比，孕妇患严重COVID-19的风险增加。此外，不同的研究表明，严重的COVID-19主要限于未接种疫苗的女性。本研究的目的是根据COVID-19孕妇的疫苗接种状况确定孕妇的不同母婴结局。进行了一项回顾性队列研究，包括2021年12月至2022年2月期间入住我们中心高危妊娠病房的所有COVID-19妇女。在纳入研究的163名女性中，60人用mRNA疫苗接种,103人未接种。妊娠结局以及产科和新生儿并发症。接种疫苗的妇女受教育程度较高，病例流行率较低，与未接种疫苗的女性相比，BMI>25。此外，接种疫苗的妇女主要是因为产科适应症，而不是与COVID相关的症状。此外,未接种疫苗的女性患COVID-19肺炎的风险明显高于接种疫苗的女性（p=0.01）。此外，妊娠和新生儿结局在两个队列中显示出一些差异.在未接种疫苗的女性中，剖腹产率较高(p=0.03)，与接种疫苗的妇女相比，其婴儿的平均出生体重百分位数受到COVID-19感染的损害（p=0.01）。基于这些结果,我们建议接受全疗程疫苗接种的妇女免受疾病严重程度的影响，SARS-Cov2感染的症状较轻，同时也呈现出更有利的妊娠结局。
