PDF(Pubmed)
Abstract：
Ultra-high dose rate radiotherapy (FLASH-RT) is an external beam radiotherapy strategy that uses an extremely high dose rate (≥40 Gy/s). Compared with conventional dose rate radiotherapy (≤0.1 Gy/s), the main advantage of FLASH-RT is that it can reduce damage of organs at risk surrounding the cancer and retain the anti-tumor effect. An important feature of FLASH-RT is that an extremely high dose rate leads to an extremely short treatment time; therefore, in clinical applications, the steps of radiotherapy may need to be adjusted. In this review, we discuss the selection of indications, simulations, target delineation, selection of radiotherapy technologies, and treatment plan evaluation for FLASH-RT to provide a theoretical basis for future research.
摘要：
超高剂量率放射治疗（FLASH-RT）是一种外束放射治疗策略，使用极高的剂量率（≥40Gy/s）。与常规剂量率放疗(≤0.1Gy/s)相比,FLASH-RT的主要优点是可以减少癌症周围危险器官的损伤并保留抗肿瘤作用。FLASH-RT的一个重要特点是极高的剂量率导致极短的治疗时间；因此，在临床应用中，放疗的步骤可能需要调整。在这次审查中,我们讨论适应症的选择，模拟,目标轮廓，放射治疗技术的选择，FLASH-RT治疗方案的评价,为今后的研究提供理论依据。
