PDF(Pubmed)
Abstract：
OBJECTIVE: This study investigated the prevalence and characteristics of comorbid conditions in patients exposed to ionizing radiation and those who were involved in the Soviet-Afghan war.
METHODS: This study analyzed the frequency and spectrum of morbidity and comorbidity in patients over a long-term period (30-35 years) following exposure to ionizing radiation at the Semipalatinsk nuclear test site or the Chornobyl nuclear power plant, and among participants of the Soviet-Afghan war. A cohort study, both prospective and retrospective, was conducted on 675 patients who underwent comprehensive examinations.
RESULTS: Numerical data were analyzed using the Statistica 6 program. The results are presented as the mean±standard deviation, median, and interquartile range (25-75th percentiles). The statistical significance of between-group differences was assessed using the Student t-test and Pearson chi-square test. A p-value of less than 0.05 was considered statistically significant. We found a high prevalence of cardiovascular diseases, including hypertension (55.0%) and cardiac ischemia (32.9%); these rates exceeded the average for this age group in the general population.
CONCLUSIONS: The cumulative impact of causal occupational, environmental, and ultra-high stress factors in the combat zone in participants of the Soviet-Afghan war, along with common conventional factors, contributed to the formation of a specific comorbidity structure. This necessitates a rational approach to identifying early predictors of cardiovascular events and central nervous system disorders, as well as pathognomonic clinical symptoms in this patient cohort. It also underscores the importance of selecting suitable methods and strategies for implementing treatment and prevention measures.
METHODS: This study analyzed the frequency and spectrum of morbidity and comorbidity in patients over a long-term period (30-35 years) following exposure to ionizing radiation at the Semipalatinsk nuclear test site or the Chornobyl nuclear power plant, and among participants of the Soviet-Afghan war. A cohort study, both prospective and retrospective, was conducted on 675 patients who underwent comprehensive examinations.
RESULTS: Numerical data were analyzed using the Statistica 6 program. The results are presented as the mean±standard deviation, median, and interquartile range (25-75th percentiles). The statistical significance of between-group differences was assessed using the Student t-test and Pearson chi-square test. A p-value of less than 0.05 was considered statistically significant. We found a high prevalence of cardiovascular diseases, including hypertension (55.0%) and cardiac ischemia (32.9%); these rates exceeded the average for this age group in the general population.
CONCLUSIONS: The cumulative impact of causal occupational, environmental, and ultra-high stress factors in the combat zone in participants of the Soviet-Afghan war, along with common conventional factors, contributed to the formation of a specific comorbidity structure. This necessitates a rational approach to identifying early predictors of cardiovascular events and central nervous system disorders, as well as pathognomonic clinical symptoms in this patient cohort. It also underscores the importance of selecting suitable methods and strategies for implementing treatment and prevention measures.
摘要：
■这项研究调查了暴露于电离辐射的患者和参与苏联-阿富汗战争的患者的合并症的患病率和特征。
这项研究分析了在塞米巴拉金斯克核试验场或切尔诺贝利核电站长期（30-35年）暴露于电离辐射后患者的发病率和合并症的频率和频谱，以及苏联-阿富汗战争的参与者。一项队列研究，前瞻性和回顾性，对675例接受全面检查的患者进行了检查。
■使用STATISTICA6程序分析数值数据。结果以平均值±标准偏差表示，中位数，和四分位数间距（第25-75百分位数）。使用Studentt检验和Pearson卡方检验评估组间差异的统计学显著性。小于0.05的P值被认为是统计学上显著的。我们发现心血管疾病的患病率很高，包括高血压(55%)和心肌缺血(32.9%);这些比率超过了普通人群中这一年龄组的平均值.
■因果职业的累积影响，环境,以及苏阿战争参与者战区的超高压力因素，以及常见的常规因素，有助于形成特定的共病结构。这就需要一种合理的方法来识别心血管事件和中枢神经系统疾病的早期预测因子。以及该患者队列中的病理相关临床症状。它还强调了选择适当的方法和战略来实施治疗和预防措施的重要性。
这项研究分析了在塞米巴拉金斯克核试验场或切尔诺贝利核电站长期（30-35年）暴露于电离辐射后患者的发病率和合并症的频率和频谱，以及苏联-阿富汗战争的参与者。一项队列研究，前瞻性和回顾性，对675例接受全面检查的患者进行了检查。
■使用STATISTICA6程序分析数值数据。结果以平均值±标准偏差表示，中位数，和四分位数间距（第25-75百分位数）。使用Studentt检验和Pearson卡方检验评估组间差异的统计学显著性。小于0.05的P值被认为是统计学上显著的。我们发现心血管疾病的患病率很高，包括高血压(55%)和心肌缺血(32.9%);这些比率超过了普通人群中这一年龄组的平均值.
■因果职业的累积影响，环境,以及苏阿战争参与者战区的超高压力因素，以及常见的常规因素，有助于形成特定的共病结构。这就需要一种合理的方法来识别心血管事件和中枢神经系统疾病的早期预测因子。以及该患者队列中的病理相关临床症状。它还强调了选择适当的方法和战略来实施治疗和预防措施的重要性。
