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Abstract：
BACKGROUND: Pleural effusion (PE) is a common clinical feature that presents a diagnostic challenge for clinicians. In this retrospective study, we aimed to assess the biomarkers, ratios, and multiple indicators in serum and Pleural effusion for the differential diagnosis of tuberculous pleural effusion (TPE) from non-tuberculosis effusion (non-TPE).
METHODS: The participants, who were divided into two groups: TPE and non-TPE (MPE and PPE), from Ningbo First Hospital, were incorporated in this study. The clinical and laboratory features were collected and analyzed using logistic regression analysis. Twelve biomarkers and their ratios in serum and PE were investigated for TPE versus non-TPE. Additionally, the value of multiple indicators for joint diagnosis was estimated.
RESULTS: Biomarkers and ratios showed good diagnostic performance. The five variables including Serum ADA, IGRA, Effusion ADA, Effusion ADA/Serum ADA and Effusion LDH/Effusion ADA were identified as valuable parameters for differential diagnosis of TPE from non-TPE. The combined diagnosis of the five indexes yielded the highest diagnostic accuracy for TPE with an AUC (0.919), sensitivity (90.30%), and specificity (94.50%).
CONCLUSIONS: The biomarkers and ratios demonstrated strong diagnostic performance, and the utilization of multiple indicators for joint diagnosis can improve the diagnostic efficacy of tuberculous pleurisy.
METHODS: The participants, who were divided into two groups: TPE and non-TPE (MPE and PPE), from Ningbo First Hospital, were incorporated in this study. The clinical and laboratory features were collected and analyzed using logistic regression analysis. Twelve biomarkers and their ratios in serum and PE were investigated for TPE versus non-TPE. Additionally, the value of multiple indicators for joint diagnosis was estimated.
RESULTS: Biomarkers and ratios showed good diagnostic performance. The five variables including Serum ADA, IGRA, Effusion ADA, Effusion ADA/Serum ADA and Effusion LDH/Effusion ADA were identified as valuable parameters for differential diagnosis of TPE from non-TPE. The combined diagnosis of the five indexes yielded the highest diagnostic accuracy for TPE with an AUC (0.919), sensitivity (90.30%), and specificity (94.50%).
CONCLUSIONS: The biomarkers and ratios demonstrated strong diagnostic performance, and the utilization of multiple indicators for joint diagnosis can improve the diagnostic efficacy of tuberculous pleurisy.
摘要：
背景：胸腔积液（PE）是一种常见的临床特征，对临床医生提出了诊断挑战。在这项回顾性研究中,我们的目的是评估生物标志物，比率，血清和胸腔积液中的多项指标用于鉴别诊断结核性胸腔积液（TPE）和非结核性胸腔积液（non-TPE）。
方法：参与者，他们分为两组：TPE和非TPE（MPE和PPE），宁波市第一医院，纳入本研究。收集临床和实验室特征，并使用Logistic回归分析进行分析。研究了TPE与非TPE的十二种生物标志物及其在血清和PE中的比率。此外,评估了多项指标对联合诊断的价值.
结果：生物标志物和比率显示出良好的诊断性能。五个变量包括血清ADA，IGRA,积液ADA,将积液ADA/血清ADA和积液LDH/积液ADA鉴定为鉴别诊断TPE和非TPE的有价值的参数。5个指标的联合诊断对TPE的诊断准确率最高,AUC为0.919,灵敏度（90.30%），和特异性（94.50%）。
结论：生物标志物和比率显示出强大的诊断性能，多指标联合诊断可提高结核性胸膜炎的诊断效能。
方法：参与者，他们分为两组：TPE和非TPE（MPE和PPE），宁波市第一医院，纳入本研究。收集临床和实验室特征，并使用Logistic回归分析进行分析。研究了TPE与非TPE的十二种生物标志物及其在血清和PE中的比率。此外,评估了多项指标对联合诊断的价值.
结果：生物标志物和比率显示出良好的诊断性能。五个变量包括血清ADA，IGRA,积液ADA,将积液ADA/血清ADA和积液LDH/积液ADA鉴定为鉴别诊断TPE和非TPE的有价值的参数。5个指标的联合诊断对TPE的诊断准确率最高,AUC为0.919,灵敏度（90.30%），和特异性（94.50%）。
结论：生物标志物和比率显示出强大的诊断性能，多指标联合诊断可提高结核性胸膜炎的诊断效能。
