Abstract：
Follicular helper T cells are a subset of CD4+ T cells that are fundamental to forming germinal centers, which are the primary sites of antibody affinity maturation and the proliferation of activated B cells. Follicular helper T cells have been extensively studied over the past 10 years, especially regarding their roles in cancer genesis. This review describes the characteristics of normal follicular helper T cells and focuses on the emerging link between follicular helper T cells and lymphomagenesis. Advances in lymphoma genetics have substantially expanded our understanding of the role of follicular helper T cells in lymphomagenesis. Moreover, we detail a range of agents and new therapies, with a major focus on chimeric antigen receptor T-cell therapy; these novel approaches may offer new treatment opportunities for patients with lymphomas.
摘要：
卵泡辅助性T细胞（Tfh）是CD4+T细胞的一个子集，是形成生发中心的基础，它们是抗体亲和力成熟和活化B细胞增殖的主要位点。Tfh细胞在过去的10年中得到了广泛的研究，特别是关于它们在癌症发生中的作用。这篇综述描述了正常Tfh细胞的特征，并重点介绍了Tfh细胞与淋巴发生之间的新联系。淋巴瘤遗传学的进展大大扩展了我们对Tfh细胞在淋巴发生中的作用的理解。此外，我们详细介绍了一系列药物和新疗法，主要关注嵌合抗原受体T细胞治疗;这些新方法可能为淋巴瘤患者提供新的治疗机会。
