Abstract：
Pseudomonas aeruginosa, an increasingly common competitive and biofilm organism in healthcare infection with sophisticated, interlinked and hierarchic quorum systems (Las, Rhl, PQS, and IQS), creates the greatest threats to the medical industry and has rendered prevailing chemotherapy medications ineffective. The rise of multidrug resistance has evolved into a concerning and potentially fatal occurrence for human life. P. aeruginosa biofilm development is assisted by exopolysaccharides, extracellular DNA, proteins, macromolecules, cellular signaling and interaction. Quorum sensing is a communication process between cells that involves autonomous inducers and regulators. Quorum-induced infectious agent biofilms and the synthesis of virulence factors have increased disease transmission, medication resistance, infection episodes, hospitalizations and mortality. Hence, quorum sensing may be a potential therapeutical target for bacterial illness, and developing quorum inhibitors as an anti-virulent tool could be a promising treatment strategy for existing antibiotics. Quorum quenching is a prevalent technique for treating infections caused by microbes because it diminishes microbial pathogenesis and increases microbe biofilm sensitivity to antibiotics, making it a potential candidate for drug development. This paper examines P. aeruginosa quorum sensing, the hierarchy of quorum sensing mechanism, quorum sensing inhibition and quorum sensing inhibitory agents as a drug development strategy to supplement traditional antibiotic strategies.
摘要：
铜绿假单胞菌,在医疗保健感染中越来越常见的竞争性和生物膜生物，相互关联和分层的法定人数系统(Las，Rhl,PQS,和IQS），对医疗行业造成了最大的威胁，并使目前的化疗药物无效。多药耐药性的上升已经演变成人类生命中令人担忧的潜在致命事件。铜绿假单胞菌生物膜的发展是由外多糖辅助，胞外DNA，蛋白质，大分子,细胞信号和相互作用。群体感应是细胞之间的通信过程，涉及自主诱导者和调节器。群体诱导的感染因子生物膜和毒力因子的合成增加了疾病传播，抗药性,感染发作,住院和死亡率。因此，群体感应可能是细菌性疾病的潜在治疗目标，开发群体抑制剂作为一种抗毒性工具可能是现有抗生素的一种有希望的治疗策略。群体猝灭是治疗由微生物引起的感染的普遍技术，因为它减少了微生物的发病机理并增加了微生物生物膜对抗生素的敏感性。使其成为药物开发的潜在候选者。本文研究了铜绿假单胞菌群体感应，群体感应机制的层次结构，群体感应抑制和群体感应抑制剂作为补充传统抗生素策略的药物开发策略。
