PDF(Pubmed)
Abstract：
Multiple myeloma (MM) is classically associated with organ dysfunction leading to hypercalcemia, renal insufficiency, anemia and bone disease, known as the CRAB criteria. More than 70% of patients with MM present with anemia. Few rare case reports, however, have demonstrated the presentation of MM associated with polycythemia. We present an interesting case of a 65-year-old female who was initially diagnosed with monoclonal gammopathy of undetermined significance (MGUS) which progressed to smoldering myeloma and later developed into MM. The patient also had coexisting polycythemia vera (PCV). We discuss the typical patient presentations as well as the expanded diagnostic criteria for MM. The pathophysiology explaining the coexistence of polycythemia and MM will be explored as well.
摘要：
多发性骨髓瘤（MM）通常与导致高钙血症的器官功能障碍有关，肾功能不全,贫血和骨骼疾病，称为CRAB标准。超过70%的MM患者存在贫血。很少有罕见的病例报告，然而,已证明MM与红细胞增多症相关。我们介绍了一个有趣的65岁女性病例，该女性最初被诊断患有意义不明的单克隆丙种球蛋白病（MGUS），后来发展为闷烧性骨髓瘤，后来发展为MM。患者还患有真性红细胞增多症（PCV）。我们讨论了典型的患者表现以及MM的扩展诊断标准。还将探索解释红细胞增多症和MM共存的病理生理学。
