Abstract：
UNASSIGNED: In many studies on aortic disease, women are underrepresented. The present study aims to assess sex-specific morphometric differences and gain more insight into endovascular treatment of the ascending aorta (AA) and arch.
UNASSIGNED: Electrocardiogram-gated cardiac computed tomography scans of 116 consecutive patients who were evaluated for transcatheter aortic valve replacement were retrospectively reviewed. Measurements of the AA and aortic arch were made in multiplanar views, perpendicular to the semi-automatic centerline. Multiple linear regression analysis was performed to identify predictors affecting AA and aortic arch diameter in men and women. Propensity score matching was used to investigate whether sex influences aortic morphology.
UNASSIGNED: In both sexes, body surface area (BSA) was identified as a positive predictor and diabetes as a negative predictor for aortic diameters. In men, age was identified as a positive predictor and smoking as a negative predictor for aortic diameters. Propensity score matching identified 40 pairs. Systolic and diastolic mean diameters and AA length were significantly wider in men. On average, male aortas were 7.4% wider than female aortas, both in systole and diastole.
UNASSIGNED: The present analysis demonstrates that, in women, increased BSA is associated with increased aortic arch diameters, while diabetes is associated with decreased AA and arch diameters. In men, increased BSA and age are associated with increased AA and arch diameters, while smoking and diabetes are associated with decreased AA and arch diameters. Men were confirmed to have 7.4% greater AA and arch diameters than women.
CONCLUSIONS: Men had 7.4% greater ascending aorta and arch diameters than women in a retrospective cohort, gated computed tomography-based study of 116 patients. Sex-specific differences in ascending aortic and arch size should be considered by aortic endovascular device manufacturers and physicians when developing ascending and arch endografts and planning aortic interventions.
UNASSIGNED: Electrocardiogram-gated cardiac computed tomography scans of 116 consecutive patients who were evaluated for transcatheter aortic valve replacement were retrospectively reviewed. Measurements of the AA and aortic arch were made in multiplanar views, perpendicular to the semi-automatic centerline. Multiple linear regression analysis was performed to identify predictors affecting AA and aortic arch diameter in men and women. Propensity score matching was used to investigate whether sex influences aortic morphology.
UNASSIGNED: In both sexes, body surface area (BSA) was identified as a positive predictor and diabetes as a negative predictor for aortic diameters. In men, age was identified as a positive predictor and smoking as a negative predictor for aortic diameters. Propensity score matching identified 40 pairs. Systolic and diastolic mean diameters and AA length were significantly wider in men. On average, male aortas were 7.4% wider than female aortas, both in systole and diastole.
UNASSIGNED: The present analysis demonstrates that, in women, increased BSA is associated with increased aortic arch diameters, while diabetes is associated with decreased AA and arch diameters. In men, increased BSA and age are associated with increased AA and arch diameters, while smoking and diabetes are associated with decreased AA and arch diameters. Men were confirmed to have 7.4% greater AA and arch diameters than women.
CONCLUSIONS: Men had 7.4% greater ascending aorta and arch diameters than women in a retrospective cohort, gated computed tomography-based study of 116 patients. Sex-specific differences in ascending aortic and arch size should be considered by aortic endovascular device manufacturers and physicians when developing ascending and arch endografts and planning aortic interventions.
摘要：
■在许多关于主动脉疾病的研究中，女性代表性不足。本研究旨在评估性别特异性形态差异，并更深入地了解升主动脉（AA）和弓的血管内治疗。
■对116例接受经导管主动脉瓣置换术评估的连续患者的心电图门控心脏计算机断层扫描进行回顾性分析。在多平面视图中测量AA和主动脉弓，垂直于半自动中心线。进行了多元线性回归分析，以确定影响男性和女性AA和主动脉弓直径的预测因子。倾向评分匹配用于调查性别是否影响主动脉形态。
■在两性中，体表面积(BSA)被确定为主动脉直径的阳性预测因子,糖尿病被确定为主动脉直径的阴性预测因子.在男人中，年龄是主动脉直径的阳性预测因子,吸烟是主动脉直径的阴性预测因子.倾向得分匹配确定了40对。男性的收缩和舒张平均直径和AA长度明显更宽。平均而言,男性主动脉比女性主动脉宽7.4%,在收缩期和舒张期。
■本分析表明，在女性中,BSA增加与主动脉弓直径增加相关，而糖尿病与AA和足弓直径降低有关。在男人中，BSA和年龄的增加与AA和足弓直径的增加有关，而吸烟和糖尿病与AA和足弓直径降低有关。确认男性的AA和足弓直径比女性大7.4％。
结论：在回顾性队列研究中，男性的升主动脉和弓直径比女性大7.4％，基于门控计算机断层扫描的116例患者研究。主动脉血管内装置制造商和医生在进行升主动脉和弓内移植物和计划主动脉干预时，应考虑升主动脉和弓大小的性别差异。
■对116例接受经导管主动脉瓣置换术评估的连续患者的心电图门控心脏计算机断层扫描进行回顾性分析。在多平面视图中测量AA和主动脉弓，垂直于半自动中心线。进行了多元线性回归分析，以确定影响男性和女性AA和主动脉弓直径的预测因子。倾向评分匹配用于调查性别是否影响主动脉形态。
■在两性中，体表面积(BSA)被确定为主动脉直径的阳性预测因子,糖尿病被确定为主动脉直径的阴性预测因子.在男人中，年龄是主动脉直径的阳性预测因子,吸烟是主动脉直径的阴性预测因子.倾向得分匹配确定了40对。男性的收缩和舒张平均直径和AA长度明显更宽。平均而言,男性主动脉比女性主动脉宽7.4%,在收缩期和舒张期。
■本分析表明，在女性中,BSA增加与主动脉弓直径增加相关，而糖尿病与AA和足弓直径降低有关。在男人中，BSA和年龄的增加与AA和足弓直径的增加有关，而吸烟和糖尿病与AA和足弓直径降低有关。确认男性的AA和足弓直径比女性大7.4％。
结论：在回顾性队列研究中，男性的升主动脉和弓直径比女性大7.4％，基于门控计算机断层扫描的116例患者研究。主动脉血管内装置制造商和医生在进行升主动脉和弓内移植物和计划主动脉干预时，应考虑升主动脉和弓大小的性别差异。
