Abstract：
Probiotics must survive in foods and passage through the human mouth, stomach, and small intestine to reach the colon in a viable state and exhibit their beneficial health effects. Probiotic viability can be improved by encapsulating them inside hydrogel-based delivery systems. These systems typically comprise a 3D network of cross-linked polymers that retain large amounts of water within their pores. This study discussed the stability of probiotics and morphology of hydrogel beads after encapsulation, encapsulation efficiency, utilization of natural polymers, and encapsulation mechanisms. Examples of the application of these hydrogel-based delivery systems are then given. These studies show that encapsulation of probiotics in hydrogels can improve their viability, provide favorable conditions in the food matrix, and control their release for efficient colonization in the large intestine. Finally, we highlight areas where future research is required, such as the large-scale production of encapsulated probiotics and the in vivo testing of their efficacy using animal and human studies.
摘要：
益生菌必须在食物中存活并通过人类口腔，胃,和小肠以存活状态到达结肠，并表现出有益的健康效果。益生菌活力可以通过将它们封装在基于水凝胶的递送系统中来改善。这些系统通常包含交联聚合物的3D网络,其在其孔内保留大量水。本研究讨论了益生菌的稳定性和水凝胶珠封装后的形态，封装效率，利用天然聚合物，和封装机制。然后给出这些基于水凝胶的递送系统的应用实例。这些研究表明，将益生菌封装在水凝胶中可以提高其生存能力，在食物基质中提供有利条件，并控制它们的释放以在大肠中有效定植。最后,我们强调需要未来研究的领域，例如大规模生产封装的益生菌，以及使用动物和人体研究对其功效进行体内测试。
