Abstract：
BACKGROUND: The knowledge of patients\' perceptions of factors contributing to ulcerative colitis (UC) flares is limited; however, online patient communications could offer insight. This analysis aimed to identify the most frequent patient-reported triggers and symptoms of UC flares, which could highlight potential interventions for outcome improvement.
METHODS: Online posts written pre- and postflare by patients with UC on 8 public forums in 6 countries between January 1, 2019, and February 14, 2021, were identified using flare-related keywords. Flare-related posts were captured and Netbase Quid™ artificial intelligence text analytics and natural language processing software were used to semantically map and identify commonly discussed themes and topics (subsets of themes).
RESULTS: Of >27 000 patient posts, 12 900 were identified as flare related. The most frequent themes were treatment experiences and side effects (28.5% of posts), followed by flare symptoms (22.9% of posts). The most frequent topic was emotional/peer support (9.4% of posts), followed by experiences with mesalamine (and other oral/rectal formulations; 8.0% of posts), and dietary recommendations (6.0% of posts). Stress and anxiety were the most frequently reported flare triggers (37.9% of posts), followed by diet (28.4% of posts). Stress and anxiety were frequently identified as both triggers for, and general symptoms of, flare. Blood in the stool was the most discussed flare indicator (57.8% of posts).
CONCLUSIONS: Frequently discussed patient-perceived triggers of UC flares included diet, stress, and anxiety. These results suggest that physicians could incorporate a broader and more holistic approach to UC monitoring and management than is currently practiced.
The patient-reported triggers of flares that were most frequently discussed in online forum posts are not routinely monitored during ulcerative colitis management, emphasizing the need for physicians to incorporate a broader, more holistic approach to ulcerative colitis management than currently practiced.
METHODS: Online posts written pre- and postflare by patients with UC on 8 public forums in 6 countries between January 1, 2019, and February 14, 2021, were identified using flare-related keywords. Flare-related posts were captured and Netbase Quid™ artificial intelligence text analytics and natural language processing software were used to semantically map and identify commonly discussed themes and topics (subsets of themes).
RESULTS: Of >27 000 patient posts, 12 900 were identified as flare related. The most frequent themes were treatment experiences and side effects (28.5% of posts), followed by flare symptoms (22.9% of posts). The most frequent topic was emotional/peer support (9.4% of posts), followed by experiences with mesalamine (and other oral/rectal formulations; 8.0% of posts), and dietary recommendations (6.0% of posts). Stress and anxiety were the most frequently reported flare triggers (37.9% of posts), followed by diet (28.4% of posts). Stress and anxiety were frequently identified as both triggers for, and general symptoms of, flare. Blood in the stool was the most discussed flare indicator (57.8% of posts).
CONCLUSIONS: Frequently discussed patient-perceived triggers of UC flares included diet, stress, and anxiety. These results suggest that physicians could incorporate a broader and more holistic approach to UC monitoring and management than is currently practiced.
The patient-reported triggers of flares that were most frequently discussed in online forum posts are not routinely monitored during ulcerative colitis management, emphasizing the need for physicians to incorporate a broader, more holistic approach to ulcerative colitis management than currently practiced.
摘要：
背景：患者对溃疡性结肠炎（UC）耀斑因素的认识有限；然而，在线患者沟通可以提供洞察力。本分析旨在确定患者报告的UC耀斑最常见的诱因和症状。这可能突出了改善结果的潜在干预措施。
方法：在2019年1月1日至2021年2月14日期间，UC患者在6个国家的8个公共论坛上撰写的耀斑前和后的在线帖子使用耀斑相关关键词进行识别。捕获与Flare相关的帖子，并使用NetbaseQuid™人工智能文本分析和自然语言处理软件来语义映射和识别通常讨论的主题和主题（主题子集）。
结果：在>27000个患者帖子中，12900被确定为耀斑相关。最常见的主题是治疗经验和副作用（占职位的28.5％），其次是耀斑症状(22.9%的职位)。最常见的话题是情感/同伴支持（占帖子的9.4％），其次是美沙拉嗪(和其他口服/直肠制剂；8.0%的职位)的经验，和饮食建议(占职位的6.0%)。压力和焦虑是最常报告的耀斑触发因素(37.9%的帖子)，其次是饮食（28.4%的职位）。压力和焦虑经常被认为是触发因素，和一般症状，flare.粪便中的血液是讨论最多的耀斑指标（占职位的57.8％）。
结论：经常讨论的UC耀斑的患者感知触发因素包括饮食，压力，和焦虑。这些结果表明，医生可以采用比目前更广泛，更全面的方法来监测和管理UC。
在溃疡性结肠炎管理期间，未常规监测在在线论坛帖子中最频繁讨论的患者报告的耀斑触发因素。强调医生需要纳入更广泛的，比目前实践的更全面的溃疡性结肠炎管理方法。
方法：在2019年1月1日至2021年2月14日期间，UC患者在6个国家的8个公共论坛上撰写的耀斑前和后的在线帖子使用耀斑相关关键词进行识别。捕获与Flare相关的帖子，并使用NetbaseQuid™人工智能文本分析和自然语言处理软件来语义映射和识别通常讨论的主题和主题（主题子集）。
结果：在>27000个患者帖子中，12900被确定为耀斑相关。最常见的主题是治疗经验和副作用（占职位的28.5％），其次是耀斑症状(22.9%的职位)。最常见的话题是情感/同伴支持（占帖子的9.4％），其次是美沙拉嗪(和其他口服/直肠制剂；8.0%的职位)的经验，和饮食建议(占职位的6.0%)。压力和焦虑是最常报告的耀斑触发因素(37.9%的帖子)，其次是饮食（28.4%的职位）。压力和焦虑经常被认为是触发因素，和一般症状，flare.粪便中的血液是讨论最多的耀斑指标（占职位的57.8％）。
结论：经常讨论的UC耀斑的患者感知触发因素包括饮食，压力，和焦虑。这些结果表明，医生可以采用比目前更广泛，更全面的方法来监测和管理UC。
在溃疡性结肠炎管理期间，未常规监测在在线论坛帖子中最频繁讨论的患者报告的耀斑触发因素。强调医生需要纳入更广泛的，比目前实践的更全面的溃疡性结肠炎管理方法。
