PDF(Pubmed)
Abstract：
UNASSIGNED: To the best of our knowledge, Androgen receptor (AR) and cluster of differentiation 24 (CD24) expression in bladder urothelial carcinoma (UC) has not yet been reported in our population. The aim of this study was to evaluate the expression of both markers in UCB using immunohistochemistry.
UNASSIGNED: Data from 60 patients with UCB were obtained between 2009 and 2018. The samples were divided into four groups based on their smoking history. Group 1 included non-smokers, group 2 smoked <20 cigarettes/day for 30 years, group 3 smoked for 31-40 years, and group 4 smoked for > 40 years. Each group then divided into Non muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC) subgroups. The smear was stained with hematoxylin and eosin (HE) - immunohistochemistry of CD24 and RA, followed by histoscore assessment.
UNASSIGNED: The male to female smoking rates was 1.8. Based on gender, in the NMIBC group there were 85.7% men and 14.3% were women while in MIBC 74.4% men and 25.6% women. The mean age of the NMIBC and MIBC groups was 56.3 years and 54.5 years, respectively. There was no significant relationship between smoking status in group 2 (OR 0.31, CI 95% CI, p=0,39), group 3 (OR 013, CI 95% CI, p=0,05), and group 4 (OR 0.23, CI 95% CI, p=0215) to the UCB invasiveness. A significant relationship was observed between cytoplasmic AR expression and UCB invasiveness (OR 0.14[0,04; 0.47], CI 95%, p=0.001). There was no significant relationship between RA in the nucleus and UCB invasion (OR 1.09[0,18; 6.48] CI 95%, p=1000). No significant relationship was observed between CD24 expression and UCB invasiveness (OR 0.81[0,27-2,45] CI 95%, p=0712).
UNASSIGNED: Cytoplasmic AR expression is associated with UCB invasiveness. Smoking history and CD24 expression were not associated with UCB invasion.
UNASSIGNED: Data from 60 patients with UCB were obtained between 2009 and 2018. The samples were divided into four groups based on their smoking history. Group 1 included non-smokers, group 2 smoked <20 cigarettes/day for 30 years, group 3 smoked for 31-40 years, and group 4 smoked for > 40 years. Each group then divided into Non muscle invasive bladder cancer (NMIBC) and muscle invasive bladder cancer (MIBC) subgroups. The smear was stained with hematoxylin and eosin (HE) - immunohistochemistry of CD24 and RA, followed by histoscore assessment.
UNASSIGNED: The male to female smoking rates was 1.8. Based on gender, in the NMIBC group there were 85.7% men and 14.3% were women while in MIBC 74.4% men and 25.6% women. The mean age of the NMIBC and MIBC groups was 56.3 years and 54.5 years, respectively. There was no significant relationship between smoking status in group 2 (OR 0.31, CI 95% CI, p=0,39), group 3 (OR 013, CI 95% CI, p=0,05), and group 4 (OR 0.23, CI 95% CI, p=0215) to the UCB invasiveness. A significant relationship was observed between cytoplasmic AR expression and UCB invasiveness (OR 0.14[0,04; 0.47], CI 95%, p=0.001). There was no significant relationship between RA in the nucleus and UCB invasion (OR 1.09[0,18; 6.48] CI 95%, p=1000). No significant relationship was observed between CD24 expression and UCB invasiveness (OR 0.81[0,27-2,45] CI 95%, p=0712).
UNASSIGNED: Cytoplasmic AR expression is associated with UCB invasiveness. Smoking history and CD24 expression were not associated with UCB invasion.
摘要：
■据我们所知,雄激素受体（AR）和分化簇24（CD24）在膀胱尿路上皮癌（UC）中的表达在我们人群中尚未报道。这项研究的目的是使用免疫组织化学评估两种标志物在UCB中的表达。
■从2009年至2018年期间获得了60例UCB患者的数据。根据吸烟史将样品分为四组。第一组包括不吸烟者，第2组吸烟<20支/天，持续30年，第三组吸烟31-40年，第4组吸烟超过40年。每组再分为非肌层浸润性膀胱癌(NMIBC)和肌层浸润性膀胱癌(MIBC)亚组。涂片用苏木精和伊红（HE）染色-CD24和RA的免疫组织化学，其次是组织评分评估。
■男女吸烟率为1.8。基于性别,在NMIBC组中，男性占85.7%，女性占14.3%，而在MIBC组中，男性占74.4%，女性占25.6%。NMIBC和MIBC组的平均年龄分别为56.3岁和54.5岁，分别。第2组的吸烟状况之间没有显着关系（OR0.31，CI95％CI，p=0,39），第3组(OR013，CI95%CI，p=0.05)，和第4组(OR0.23，CI95%CI，p=0215)对UCB侵袭性。细胞质AR表达与UCB侵袭之间存在显着关系（OR0.14[0,04;0.47]，CI95%，p=0.001)。核内RA与UCB侵袭之间无显著关系(OR1.09[0,18;6.48]CI95%,p=1000）。CD24表达与UCB侵袭性之间无显著关系(OR0.81[0,27-2,45]CI95%，p=0712）。
■细胞质AR表达与UCB侵袭性相关。吸烟史和CD24表达与UCB侵袭无关。
■从2009年至2018年期间获得了60例UCB患者的数据。根据吸烟史将样品分为四组。第一组包括不吸烟者，第2组吸烟<20支/天，持续30年，第三组吸烟31-40年，第4组吸烟超过40年。每组再分为非肌层浸润性膀胱癌(NMIBC)和肌层浸润性膀胱癌(MIBC)亚组。涂片用苏木精和伊红（HE）染色-CD24和RA的免疫组织化学，其次是组织评分评估。
■男女吸烟率为1.8。基于性别,在NMIBC组中，男性占85.7%，女性占14.3%，而在MIBC组中，男性占74.4%，女性占25.6%。NMIBC和MIBC组的平均年龄分别为56.3岁和54.5岁，分别。第2组的吸烟状况之间没有显着关系（OR0.31，CI95％CI，p=0,39），第3组(OR013，CI95%CI，p=0.05)，和第4组(OR0.23，CI95%CI，p=0215)对UCB侵袭性。细胞质AR表达与UCB侵袭之间存在显着关系（OR0.14[0,04;0.47]，CI95%，p=0.001)。核内RA与UCB侵袭之间无显著关系(OR1.09[0,18;6.48]CI95%,p=1000）。CD24表达与UCB侵袭性之间无显著关系(OR0.81[0,27-2,45]CI95%，p=0712）。
■细胞质AR表达与UCB侵袭性相关。吸烟史和CD24表达与UCB侵袭无关。
