PDF(Pubmed)
Abstract：
BACKGROUND: Haemophilus influenzae (Hi) commonly causes invasive and noninvasive bacterial infections. Nationwide investigation on the carriage characteristics of H influenzae in healthy children in China is lacking. We reviewed the prevalence of H influenzae infections in this population.
METHODS: PubMed, CNKI, Wanfang, VIP, and CBM databases were electronically searched to collect cross-sectional studies on the prevalence of Hi among healthy children in China from inception to November 2021. Two reviewers independently screened the literature, extracted the data, and assessed the risk of bias in the included studies. Meta-analysis was performed using Stata 14.0.
RESULTS: A total of 28 studies involving 14,301 children were included, among whom there were 2878 children with Hi. The pooled carriage rate of Hi was 0.21 (95% CI: 0.17-0.25). Subgroup analysis indicated no significant sex- or age-related differences. The proportion of Hi in winter (29%) was higher than that in other seasons. Results indicated significant differences among the provinces, with carriage proportions ranging from 0.11 to 0.60. The proportion of nontypeable H influenzae (NTHi) was higher than that of the capsular type. The proportion of Hib in the capsular type (2%) was higher than that in other serotypes.
CONCLUSIONS: The carriage rate of Hi in healthy children in China was 21% with no sex-related age differences. The proportion of Hi in winter was high, and the proportions of Hi in different regions were significantly different. NTHi was the predominant serotype detected in children.
METHODS: PubMed, CNKI, Wanfang, VIP, and CBM databases were electronically searched to collect cross-sectional studies on the prevalence of Hi among healthy children in China from inception to November 2021. Two reviewers independently screened the literature, extracted the data, and assessed the risk of bias in the included studies. Meta-analysis was performed using Stata 14.0.
RESULTS: A total of 28 studies involving 14,301 children were included, among whom there were 2878 children with Hi. The pooled carriage rate of Hi was 0.21 (95% CI: 0.17-0.25). Subgroup analysis indicated no significant sex- or age-related differences. The proportion of Hi in winter (29%) was higher than that in other seasons. Results indicated significant differences among the provinces, with carriage proportions ranging from 0.11 to 0.60. The proportion of nontypeable H influenzae (NTHi) was higher than that of the capsular type. The proportion of Hib in the capsular type (2%) was higher than that in other serotypes.
CONCLUSIONS: The carriage rate of Hi in healthy children in China was 21% with no sex-related age differences. The proportion of Hi in winter was high, and the proportions of Hi in different regions were significantly different. NTHi was the predominant serotype detected in children.
摘要：
背景：流感嗜血杆菌（Hi）通常引起侵袭性和非侵袭性细菌感染。缺乏对中国健康儿童流感嗜血杆菌携带特征的全国性调查。我们回顾了该人群中流感嗜血杆菌感染的患病率。
方法：PubMed，CNKI,万方,VIP,和CBM数据库进行了电子搜索，以收集从开始到2021年11月中国健康儿童中Hi患病率的横断面研究。两位审稿人独立筛选了文献，提取数据，并评估纳入研究的偏倚风险。采用Stata14.0进行Meta分析。
结果：共纳入28项研究，涉及14,301名儿童，其中有2878名Hi儿童。Hi的合并携带率为0.21(95%CI:0.17-0.25)。亚组分析显示没有显著的性别或年龄相关差异。冬季Hi的比例（29％）高于其他季节。结果表明，各省之间存在显著差异，车厢比例范围从0.11到0.60。不可分型的流感嗜血杆菌（NTHi）的比例高于荚膜型。Hib在荚膜型中的比例（2％）高于其他血清型。
结论：中国健康儿童Hi的携带率为21％，无性别年龄差异。冬季Hi的比例很高，不同地区Hi的比例差异显著。NTHi是在儿童中检测到的主要血清型。
方法：PubMed，CNKI,万方,VIP,和CBM数据库进行了电子搜索，以收集从开始到2021年11月中国健康儿童中Hi患病率的横断面研究。两位审稿人独立筛选了文献，提取数据，并评估纳入研究的偏倚风险。采用Stata14.0进行Meta分析。
结果：共纳入28项研究，涉及14,301名儿童，其中有2878名Hi儿童。Hi的合并携带率为0.21(95%CI:0.17-0.25)。亚组分析显示没有显著的性别或年龄相关差异。冬季Hi的比例（29％）高于其他季节。结果表明，各省之间存在显著差异，车厢比例范围从0.11到0.60。不可分型的流感嗜血杆菌（NTHi）的比例高于荚膜型。Hib在荚膜型中的比例（2％）高于其他血清型。
结论：中国健康儿童Hi的携带率为21％，无性别年龄差异。冬季Hi的比例很高，不同地区Hi的比例差异显著。NTHi是在儿童中检测到的主要血清型。
