PDF(Pubmed)
Abstract：
The aim of this study was to investigate the subsequent early pregnancy outcomes in women positive for non-criteria antiphospholipid antibodies (NC-aPLs) before pregnancy. A total of 273 patients who had experienced sporadic or recurrent pregnancy loss and had been screened for 13 NC-aPLs at preconception were recruited in this study from September 2019 to February 2022. Serum levels of NC-aPLs were measured by ELISA using specific kits. The primary outcome was early pregnancy loss, and the secondary outcomes were biochemical pregnancy, clinically confirmed pregnancy loss, and ongoing pregnancy. Among these subjects, 56 patients had one previous pregnancy loss, and 217 had recurrent pregnancy loss (RPL). The NC-aPLs (+) and NC-aPLs (-) groups had similar rates of early pregnancy loss (EPL) after adjustment, regardless of the number of positive NC-aPLs (aOR = 1.054, 95% CI 0.602-1.846). Other outcomes were comparable in both groups, including the rates of biochemical pregnancy (aOR = 1.344, 95% CI 0.427-4.236), clinically confirmed pregnancy loss (aOR = 0.744, 95% CI 0.236-2.344), and ongoing pregnancy (aOR = 0.949, 95% CI 0.542-1.660). Based on sensitivity analysis, the NC-aPLs (+) were not associated with adverse early pregnancy outcomes in women with RPL. Furthermore, the difference in gestational weeks of pregnancy loss between the two groups was also insignificant. This study found no evidence linking preconception NC-aPL positivity to early pregnancy outcomes but offers a reference for future research to clarify NC-aPLs\' potential clinical impact.
摘要：
这项研究的目的是调查怀孕前非标准抗磷脂抗体（NC-aPLs）阳性的女性随后的早期妊娠结局。从2019年9月至2022年2月，本研究共招募了273例经历过零星或复发性妊娠流产并在孕前筛查了13例NC-aPLs的患者。使用特异性试剂盒通过ELISA测量NC-aPL的血清水平。主要结果是早期妊娠丢失，次要结局是生化妊娠，临床证实的妊娠丢失，和持续怀孕。在这些科目中，56名患者有一次怀孕失败，217例反复妊娠丢失（RPL）。NC-aPLs(+)和NC-aPLs(-)组调整后早期妊娠丢失率(EPL)相似,无论阳性NC-aPL的数量如何(aOR=1.054，95%CI0.602-1.846)。两组的其他结果具有可比性，包括生化妊娠率（aOR=1.344，95%CI0.427-4.236），临床证实的妊娠丢失（aOR=0.744，95%CI0.236-2.344），和持续妊娠（aOR=0.949，95%CI0.542-1.660）。基于敏感性分析，在患有RPL的女性中,NC-aPLs(+)与不良早期妊娠结局无关.此外，两组妊娠丢失的孕周差异也不显著.这项研究没有发现将孕前NC-aPL阳性与早期妊娠结局联系起来的证据，但为未来的研究提供了参考，以阐明NC-aPL的潜在临床影响。
